Inhibition of nitric oxide formation by guanidines.

doi:10.1016/0014-2999(93)90667-7

Paper

Inhibition of nitric oxide formation by guanidines.

Published Nov 2, 1993 · Khalid S Hasan, B. J. Heesen, B. J. Heesen

European journal of pharmacology

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162

Citations

2

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Highly Cited

Study Snapshot

Aminoguanidine selectively inhibits the inducible isoform of nitric oxide synthase, while 1,1-dimethylguanidine is a relatively potent inhibitor of both cytokine-induced and vascular constitutive isoforms of NO synthase.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Inhibition of nitric oxide formation by guanidines.

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References

Nitric oxide localized to spinal cords of mice with experimental allergic encephalomyelitis: an electron paramagnetic resonance study

Nitric oxide may play a role in the disease process of experimental allergic encephalomyelitis and possibly multiple sclerosis.

Identification of inhibitors of nitric oxide synthase that do not interact with the endothelial cell l‐arginine transporter

Inhibitors of nitric oxide synthase can selectively modulate endothelial cell l-arginine transport or NO synthase activity, revealing the role of the arginine transporter in NO biosynthesis regulation.

Aminoguanidine, a Novel Inhibitor of Nitric Oxide Formation, Prevents Diabetic Vascular Dysfunction

Aminoguanidine effectively prevents diabetic vascular dysfunction by inhibiting nitric oxide production, suggesting a role for nitric oxide in diabetic vascular complications.

Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase.

Brain nitric oxide synthase can form hydrogen peroxide at suboptimal concentrations of L-arginine or H4biopterin, and N omega-nitro-substituted L-arginine analogues can effectively block this reaction.

Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.

The particulate endothelium-derived relaxing factor synthase, which is essential for its function, can be purified from cultured and native bovine aortic endothelial cells, with a 12% recovery.

Citations

Chemical similarities and differences among inhibitors of nitric oxide synthase, arginase and dimethylarginine dimethylaminohydrolase-1: Implications for the design of novel enzyme inhibitors modulating the nitric oxide pathway.

Estrous Cycle and Early Pregnancy of White Mice Exposed to Methomyl

Quinazolinones, Quinazolinthiones, and Quinazolinimines as Nitric Oxide Synthase Inhibitors: Synthetic Study and Biological Evaluation

Guanidines from 'toxic substances' to compounds with multiple biological applications--detailed outlook on synthetic procedures employed for the synthesis of guanidines.

Advances in Ocular Toxicology