Paper
Inhibition of neuronal nitric oxide synthase by 7-methoxyindazole and related substituted indazoles.
Published May 7, 2001 · P. Schumann, V. Collot, Y. Hommet
Bioorganic & medicinal chemistry letters
Q2 SJR score
47
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
7-methoxyindazole is the most active compound in inhibiting neuronal nitric oxide synthase and has antinociceptive properties, demonstrating that nitro-substitution is not essential for biological activity.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
7-Nitro-1H-indazole, an inhibitor of nitric oxide synthase.
7-nitro-1H-indazole, an inhibitor of nitric oxide synthase, shows an intramolecular hydrogen bond and intermolecular hydrogen bonding, providing insights into its mechanism of action.
2000·6citations·J. Sopková-de Oliveira Santos et al.·Acta crystallographica. Section C, Crystal structure communications
Acta crystallographica. Section C, Crystal structure communications
Endogenous nitric oxide synthesis: biological functions and pathophysiology.
Nitric oxide plays a crucial role in neuronal communication, blood vessel modulation, and immune response, with its overactivation leading to various pathophysiological conditions and diseases.
1999·790citations·D. Bredt·Free radical research
Free radical research
Crystal Structures of Zinc-free and -bound Heme Domain of Human Inducible Nitric-oxide Synthase
The crystal structures of human inducible nitric-oxide synthase (NOS-2) reveal conserved quaternary structure, tertiary topology, and substrate and cofactor binding sites, providing insights for isoform-specific inhibitor design.
1999·198citations·Huiying Li et al.·The Journal of Biological Chemistry
The Journal of Biological Chemistry
Suzuki-type cross-coupling reaction of 3-iodoindazoles with aryl boronic acids: A general and flexible route to 3-arylindazoles
The Suzuki-type cross-coupling reaction of 3-iodoindazoles with aryl and heteroaryl boronic acids provides a flexible route to 3-arylindazoles, potentially useful for treating cardiovascular diseases and erectile dysfunction.
1999·70citations·V. Collot et al.·Tetrahedron
Tetrahedron
Crystal Structure of Constitutive Endothelial Nitric Oxide Synthase A Paradigm for Pterin Function Involving a Novel Metal Center
The crystal structure of endothelial nitric oxide synthase reveals a novel metal center and potential catalytic cycle involving a cationic pterin radical.
1998·573citations·C. Raman et al.·Cell
Cell
Citations
Synthesis, in vitro, and in silico evaluation of Indazole Schiff bases as potential α-glucosidase inhibitors
Indazole Schiff bases synthesized in this study show potential as potent -glucosidase inhibitors, with compound 1 being the most potent.
2021·27citations·Bushra et al.·Journal of Molecular Structure
Journal of Molecular Structure
Arylation of indoles using cyclohexanones dually-catalyzed by niobic acid and palladium-on-carbons.
3-Arylindoles can be easily constructed from indoles and cyclohexanone derivatives using a combination of catalytic niobic acid-on-carbon and palladium-on-carbon under heating conditions without oxidants.
2020·0citations·Kazuho Ban et al.·Organic & biomolecular chemistry
Organic & biomolecular chemistry
Indazole derivatives and their therapeutic applications: a patent review (2013-2017)
Indazole derivatives show promising anticancer, anti-inflammatory, and neurodegeneration properties, with potential applications in disorders involving protein kinases and neurodegeneration.
2018·80citations·Ireen Denya et al.·Expert Opinion on Therapeutic Patents
Expert Opinion on Therapeutic Patents
Coordination compounds of 4,5,6,7-tetrahydro-1H-indazole with Cu(II), Co(II) and Ag(I): structural, antimicrobial, antioxidant and enzyme inhibition studies
4,5,6,7-tetrahydro-1H-indazole complexes with Cu(II), Co(II), and Ag(I) show antibacterial, antifungal, and antioxidant properties, with potential applications in pharmaceuticals.
2017·25citations·Ezzat Khan et al.·Journal of Coordination Chemistry
Journal of Coordination Chemistry
Copolymerization of an indazole ligand into the self-polymerization of dopamine for enhanced binding with metal ions.
The 1:3 copolymer of DHI and dopamine enhances colloidal stability and provides additional functionality for biomedical applications using transition metal-based cargo carriers.
2015·24citations·K. Fan et al.·Journal of materials chemistry. B
Journal of materials chemistry. B
Two‐Step Synthesis of Blue Luminescent (Pyrrol‐3‐yl)‐1H‐(aza)indazoles Based on a Three‐Component Coupling–Cyclocondensation Sequence
This two-step process efficiently prepares blue lumiescent (Pyrrol-3-yl)-1H-(aza)indazoles with high fluorescence quantum yields and potential for ON/OFF fluorescence switching systems in narrow pH-ranges.
2015·7citations·J. Nordmann et al.·European Journal of Organic Chemistry
European Journal of Organic Chemistry
[3 + 2] Cycloaddition of arynes with CF3CHN2: Access to 3-trifluoromethyl-1H-indazoles
This study developed an efficient [3 + 2] cycloaddition reaction of arynes and CF3CHN2 in the presence of fluoride, enabling the access to biologically active 3-trifluoromethyl-1H-indazoles from readily available starting materials.
2015·38citations·Long Sun et al.·Journal of Fluorine Chemistry
Journal of Fluorine Chemistry
Synthesis of indazole motifs and their medicinal importance: an overview.
Novel synthetic routes for indazole motifs show potential for antibacterial, anti-depressant, and anti-inflammatory pharmaceuticals, with potential applications in anti-hypertensive and anti-cancer treatments.
2015·229citations·D. D. Gaikwad et al.·European journal of medicinal chemistry
European journal of medicinal chemistry