Inhibition of in vitro Heme Synthesis from N15-Glycine by 2-Ethyl-5-methylbenzimidazole.∗, †

doi:10.3181/00379727-86-21138

Paper

Inhibition of in vitro Heme Synthesis from N15-Glycine by 2-Ethyl-5-methylbenzimidazole.∗, †

Published Jul 1, 1954 · L. D. Abbott, M. J. Dodson

Proceedings of the Society for Experimental Biology and Medicine

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Abstract

Summary 2-Ethyl-5-methylbenzimidazole was found to be considerably more inhibitory than 2,5-dimethylbenzimidazole, or benzimi-dazole, for the synthesis of heme by chicken erythrocytes incubated in vitro. This was in the same relative order of inhibitory activities as was noted for multiplication of influenza A or B virus, and is considered to add further support to the concept that the same basic mechanism, possibly involving a fundamental role of nucleic acid in biosynthesis, underlies both processes.

Study Snapshot

2-Ethyl-5-methylbenzimidazole is more inhibitory than 2,5-dimethylbenzimidazole for heme synthesis in chicken erythrocytes, suggesting a possible nucleic acid role in biosynthesis.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Inhibition of in vitro Heme Synthesis from N15-Glycine by 2-Ethyl-5-methylbenzimidazole.∗, †

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References

Citations

The Storage of Chicken and Turkey Spermatozoa by Inhibition with 2-ethyl-5-methylbenzimidazole (EBM)

Inhibition with 2-ethyl-5-methylbenzimidazole (EMB) can extend the storage period of chicken spermatozoa, potentially improving fertility.

SELECTIVE CHEMICAL INHIBITION OF INFLUENZA B VIRUS MULTIPLICATION

The most potent influenza B virus inhibitors have low toxicity, with their selectivity related to the presence of the f-D-ribofuranose moiety at NI in the imidazole ring.

Developing Chick Embryo Lethal Response to Dose Variation of 2-Ethyl-5-Methylbenzimidazole

Dose response in developing chick embryos can reveal metabolic changes related to specific inhibitors, aiding in understanding embryonic development.

Inhibitory Effects of Certain Benzimidazole Derivatives on the Production of Azo Dye Liver Tumors

Feeding 2,5-dimethylbenzimidazole or 2-ethyl-5-methylbenzimidazole at 0.5 percent in the diet can completely prevent liver tumor induction by azo dyes, while benzotriazole and 5-methylbenzotriazole are ineffective.