Paper
Insertion of 5-methyl-N4-(1-pyrenylmethyl)cytidine into DNA. Duplex, three-way junction and triplex stabilities
Published Nov 25, 1996 · A. Abdel-Rahman, O. Ali, E. Pedersen
Tetrahedron
Q3 SJR score
15
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Study Snapshot
Inserting 5-methyl-N4-(1-pyrenylmethyl)cytidine into DNA stabilizes duplexes, three-way junctions, and triplexes, potentially offering new antisense oligo targets on intact secondary structures.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Solution conformation of [AF]dG opposite a -2 deletion site in a DNA duplex: intercalation of the covalently attached aminofluorene ring into the helix with base displacement of the C8-modified syn guanine and adjacent unpaired 3'-adenine into the major groove.
The solution conformation of the [AF]dG adduct opposite a -2 deletion site in DNA reveals a wedge-shaped intercalation site with pronounced propeller-twisting and buckling.
1995·11citations·B. Mao et al.·Biochemistry
Biochemistry
Refined solution structure of 8,9-dihydro-8-(N7-guanyl)-9-hydroxyaflatoxin B1 opposite CpA in the complementary strand of an oligodeoxynucleotide duplex as determined by 1H NMR.
The refined solution structure of aflatoxin B1 shows that the stability of this modified oligodeoxynucleotide cannot reliably predict the frequency of frame shifts.
1995·20citations·D. S. Johnston et al.·Biochemistry
Biochemistry
NMR solution structure of a nonanucleotide duplex with a dG mismatch opposite a 10S adduct derived from trans addition of a deoxyadenosine N6-amino group to (+)-(7R,8S,9S,10R)-7,8-dihydroxy-9,10-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene: an unusual syn glycosidic torsion angle at the modified dA.
The modified dA5 in the nonanucleotide duplex adopts a syn glycosidic torsion angle, indicating a potential role in DNA repair.
1995·43citations·H. Yeh et al.·Biochemistry
Biochemistry
Relative stabilities of DNA three-way, four-way and five-way junctions (multi-helix junction loops): unpaired nucleotides can be stabilizing or destabilizing.
Unpaired bases at the branch point stabilize three- and five-way DNA junction loops, but destabilize four-way junctions, providing guidelines for improving multi-helix junction loop handling in secondary structure prediction programs.
1995·44citations·J. Kadrmas et al.·Nucleic acids research
Nucleic acids research
Solution conformation of [AF]dG opposite a -1 deletion site in a DNA duplex: intercalation of the covalently attached aminofluorene ring into the helix with base displacement of the C8-modified Syn guanine into the major groove.
The solution structure of the [AF]dG adduct opposite a deletion site in DNA reveals a unique intercalative-base displacement conformation with a covalent aminofluorene--C8-guanine adduct.
1995·14citations·B. Mao et al.·Biochemistry
Biochemistry
Citations
Conjugation of N -(3-(9-Ethynyl-6H -indolo[2,3-b ]quinoxalin-6-yl)propyl)-2,2,2-trifluoroacetamide Intercalator to a Triplex Forming Oligonucleotide, a Three-Way Junction, and a G-Quadruplex
The synthesized nucleic acid monomer Z improves thermal stability and enhances the stability of triplex forming oligonucleotides, three-way junctions, and G-quadruplexes.
2019·0citations·Amany M. A. Osman et al.·European Journal of Organic Chemistry
European Journal of Organic Chemistry
Three pyrene-modified nucleotides: synthesis and effects in secondary nucleic acid structures.
Three pyrene-modified nucleosides can stabilize nucleic acid complexes, with the 5'-position pyrene-modified nucleoside increasing duplex stability and the 2'-position pyrene-modified nucleoside decreasing duplex stability.
2012·23citations·Pawan Kumar et al.·The Journal of organic chemistry
The Journal of organic chemistry
New Thymine-Based Derivative of Nitrogen Mustards
This study successfully synthesized a new nitrogen mustard derivative based on thymine, a key element in the nitrogen mustard family, using a five-step synthetic pathway.
2012·5citations·B. Boëns et al.·Nucleosides, Nucleotides & Nucleic Acids
Nucleosides, Nucleotides & Nucleic Acids
From Anionic to Cationic α‐Anomeric Oligodeoxynucleotides
Anomeric oligodeoxynucleotides show potential for antisense gene control due to their nuclease resistance and parallel orientation, making them a promising approach for gene control.
2010·15citations·F. Morvan et al.·Chemistry & Biodiversity
Chemistry & Biodiversity
Stability of Hoogsteen-type triplexes - electrostatic attraction between duplex backbone and triplex-forming oligonucleotide (TFO) using an intercalating conjugate
Novel naphthalimide TINAs show high thermal stability in Hoogsteen-type triplexes and duplexes, with potential for improved DNA stability by linking the TFO to the phosphate backbone of the duplex through ionic interaction.
2008·6citations·D. Globisch et al.·Helvetica Chimica Acta
Helvetica Chimica Acta
Alpha-beta chimeric oligo-DNA bearing intercalator-conjugated nucleobase inside the linker sequence remarkably improves thermal stability of an alternate-stranded triple helix.
Chimeric DNA with two intercalator-conjugated nucleobases at adjacent positions significantly improves the thermal stability of an alternate-stranded triple helix.
2004·7citations·A. Z. Zafrul Azam et al.·Bioorganic & medicinal chemistry letters
Bioorganic & medicinal chemistry letters
Intercalating Nucleic Acids: The Influence of Linker Length and Intercalator Type on Their Duplex Stabilities
The thermal stability of intercalating nucleic acids depends on the linker length between oligo and intercalator, with intercalator type also influencing the stability of their duplexes and triplexes.
2004·25citations·U. B. Christensen et al.·Nucleosides, Nucleotides & Nucleic Acids
Nucleosides, Nucleotides & Nucleic Acids
Intercalating nucleic acids (INAs) with insertion of N-(pyren-1-ylmethyl)-(3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol. DNA (RNA) duplex and DNA three-way junction stabilities.
Intercalating nucleic acids with N-(pyren-1-ylmethyl)-(3R,4R)-4-(hydroxymethyl)pyrrolidin-3-ol improve DNA three-way junction stability, while INA-RNA duplex stability is strongly destabilized.
2003·28citations·V. Filichev et al.·Organic & biomolecular chemistry
Organic & biomolecular chemistry
Heterocyclic modifications of oligonucleotides and antisense technology.
Heterocyclic modifications of oligonucleotides can enhance their antisense activity by improving duplex stability and influencing biological activity.
2000·89citations·P. Herdewijn·Antisense & nucleic acid drug development
Antisense & nucleic acid drug development