Insulinlike Effects of Sodium Selenate in Streptozocin-Induced Diabetic Rats

doi:10.2337/diab.40.12.1675

Paper

Insulinlike Effects of Sodium Selenate in Streptozocin-Induced Diabetic Rats

Published Dec 1, 1991 · J. McNeill, Heather L M Delgatty, M. Battell

Diabetes

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139

Citations

2

Influential Citations

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Abstract

Treatment of streptozocin (STZ)-induced diabetic rats with sodium selenate (10–15 μmol · kg−1 · day−1) for 7 wk resulted in a decrease in plasma glucose, food intake, and water intake to control or near control levels. Plasma insulin was reduced in control rats given sodium selenate to the level found in the diabetic and treated diabetic group. Treatment did not affect control rats with regard to the other measurements cited. Sodium selenate enhanced weight gain in responding diabetic rats to that seen in controls; sodium selenate's actions thus resembled those of insulin. Thus selenate, like vanadium, appears to have insulinlike effects when administered in vivo.

Non-RCT

Animal Study

Highly Cited

Study Snapshot

Sodium selenate effectively reduces blood glucose levels and enhances weight gain in streptozocin-induced diabetic rats, exhibiting insulinlike effects.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Insulinlike Effects of Sodium Selenate in Streptozocin-Induced Diabetic Rats

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References

Selenium: biochemical role as a component of glutathione peroxidase.

Selenium's nutritional effects are primarily due to its role in glutathione peroxidase, which protects hemoglobin from oxidative damage in erythrocytes.

Enhanced in vivo sensitivity of vanadyl-treated diabetic rats to insulin.

Chronic oral vanadyl treatment lowers blood glucose levels in diabetic rats, enhances insulin sensitivity, and reduces insulin dosage in spontaneously diabetic rats.

The insulin-like effects of selenate in rat adipocytes.

Selenate has insulin-like effects in rat adipocytes, stimulating glucose transport, cAMP phosphodiesterase activity, and ribosomal S6 protein phosphorylation.

Role of Abnormalities of Carbohydrate and Lipoprotein Metabolism in the Pathogenesis and Clinical Course of Hypertension

Abnormalities in carbohydrate and lipoprotein metabolism may play a role in both the etiology and clinical course of hypertension, potentially contributing to the increased risk of coronary artery disease.

Sustained prevention of myocardial and metabolic abnormalities in diabetic rats following withdrawal from oral vanadyl treatment.

Short-term oral vanadyl treatment in diabetic rats leads to beneficial changes that persist after withdrawal, suggesting a potential new treatment protocol for diabetes management.

Citations

Selenium – a scoping review for Nordic Nutrition Recommendations 2023

Selenium supplementation may have no beneficial effect on health outcomes, but low selenium intake may reduce the risk of cardiovascular diseases, cancer, and all-cause mortality.

Selenium and Selenoproteins in Health

Selenium supplementation can help regulate lipid metabolism, maintain immune function, and alleviate cardiovascular diseases, but its effect on cancer risk remains unclear and its relationship with type 2 diabetes is complex.

Administration of selenomethionine in combination with serine benefits diabetes via gut microbiota

Combined administration of selenomethionine and serine effectively reduces body weight and glucose levels in diabetic mice, with gut microbes playing a critical role in these beneficial effects.

Evaluation of Diabetes Effects of Selenium Nanoparticles Synthesized from a Mixture of Luteolin and Diosmin on Streptozotocin-Induced Type 2 Diabetes in Mice

A combination of luteolin and diosmin in selenium nanoparticles effectively restores blood glucose, lipid profile, and insulin levels in streptozotocin-induced diabetes mice, with potential for improved type 2 diabetes treatment.

Emerging Theranostic Nanomaterials in Diabetes and Its Complications

Nanomaterials offer new opportunities for diabetes diagnosis, treatment, and prevention, offering potential for new diagnostic and therapeutic approaches.