Synergistic interaction of adenylate cyclase activators and nitric oxide donor SIN-1 on platelet cyclic AMP.

doi:10.1016/0922-4106(95)90154-X

Paper

DOI: 10.1016/0922-4106(95)90154-X

Synergistic interaction of adenylate cyclase activators and nitric oxide donor SIN-1 on platelet cyclic AMP.

Published May 26, 1995 · A. Fisch, J. Michael-Hepp, J. Meyer

European journal of pharmacology

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Abstract

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In Vitro Study

Study Snapshot

SIN-1 increases platelet cGMP levels and inhibits platelet aggregation by interacting with adenylate cyclase and guanylate cyclase activators, with cGMP inhibition being the mechanism for cAMP elevation in low concentrations of adeny

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Upregulation of cAMP prevents antibody-mediated thrombus formation in COVID-19

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cAMP prevents antibody-mediated thrombus formation in COVID-19

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Molecular Mechanisms Involved in the Impairment of Boar Sperm Motility by Peroxynitrite-Induced Nitrosative Stress

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Adrenoceptor α2A signalling countervails the taming effects of synchronous cyclic nucleotide-elevation on thrombin-induced human platelet activation and aggregation.

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Aged Garlic Extract Inhibits Human Platelet Aggregation by Altering Intracellular Signaling and Platelet Shape Change.

Aged garlic extract inhibits platelet aggregation by increasing cyclic nucleotides and inhibiting fibrinogen binding and platelet shape change.

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