Interactions of trimethyl tin (TMT) with rat primary astrocyte cultures: altered uptake and efflux of rubidium,l-glutamate andD-aspartate

doi:10.1016/0006-8993(92)90131-R

Paper

Interactions of trimethyl tin (TMT) with rat primary astrocyte cultures: altered uptake and efflux of rubidium,l-glutamate andD-aspartate

Published Jun 12, 1992 · Michael Aschner, Maureen Gannon, H. Kimelberg

Brain Research

Q2 SJR score

37

Citations

2

Influential Citations

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

Low concentrations of trimethyl tin (TMT) can inhibit astrocytes' ability to maintain a transmembrane K+ gradient, potentially contributing to neurotoxicity and exacerbated swelling.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Interactions of trimethyl tin (TMT) with rat primary astrocyte cultures: altered uptake and efflux of rubidium,l-glutamate andD-aspartate

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References

Astrocytic edema in CNS trauma.

Astrocytic swelling in CNS trauma can cause potential harm, and inhibiting it with an anion transport inhibitor like L-644,711 may be beneficial in head trauma.

Methylmercury uptake in rat primary astrocyte cultures: the role of the neutral amino acid transport system

Astrocytes in the rat brain selectively uptake methylmercury-cysteine conjugates through a neutral amino acid transport system, indicating a potential link to neurotoxicity.

Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures

Swelling of astrocyte cultures leads to release of glutamate, aspartate, and taurine, which can be inhibited by anion transport inhibitors, potentially improving outcomes in brain trauma/hypoxia models.

The role of excitatory amino acids and NMDA receptors in traumatic brain injury.

NMDA antagonists may help treat acute head injury by reducing delayed tissue damage and improving bioenergetic state.

Creating Superheavy Elements

Cold fusion, using stable, naturally plentiful spherical nuclei and medium-weight projectiles, has shown promise in synthesizing superheavy elements.

Citations

Mercury in human hair and its implications for health investigation

Human hair analysis is a reliable tool for investigating potential mercury exposure and health concerns, with sources ranging from mining to food contamination.

Assessing the Association of Mitochondrial Function and Inflammasome Activation in Murine Macrophages Exposed to Select Mitotoxic Tri-Organotin Compounds

Select mitotoxic tri-organotins disrupted murine macrophage transcriptional response to LPS, yet triggered inflammasome activation, suggesting unique functional responses.

Effects of Dizocilpine, Midazolam and Their Co-Application on the Trimethyltin (TMT)-Induced Rat Model of Cognitive Deficit

The combined application of dizocilpine (MK-801) and midazolam (MK-801/Midazolam) did not show improved cognitive deficit mitigation in the trimethyltin-induced rat model.

Fabrication of hybrid PVA-PVC/SnZnOx/SWCNTs nanocomposites as Sn2+ ionic probe for environmental safety

The PVA-PVC/SnZnOx/SWCNTs nanocomposites effectively detect Sn2+ ion in environmental samples, providing a promising solution for environmental safety.

Mercury levels in human population from a mining district in Western Colombia.

High mercury levels in hair, urine, and blood are found in residents of a mining district in Colombia, with significant correlations between hair, blood, and urinary levels in both male and female individuals.