Preliminary Investigation of Antifungal Activity of 3-(3-fluoro-4- piperazine-1-phenyl)-1,3-oxazolidin-2-ones

doi:10.35652/igjps.2012.30

Paper

Preliminary Investigation of Antifungal Activity of 3-(3-fluoro-4- piperazine-1-phenyl)-1,3-oxazolidin-2-ones

Published Jan 1, 2012 · N. Pandit, Rajeev K. Singla, B. Shrivastava

Indo Global Journal of Pharmaceutical Sciences

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Abstract

Few analogues of 3-(3-fluoro-4-piperazine-1-phenyl)-1,3-oxazolidin-2-one were synthesized and structurally characterized using physical and spectral data. Current research work is to evaluate the potential of these analogues as antifungal agents. Two fungal strains, Aspergillus flavus & Penicillium chrysogenum were used in the Kirby bauer agar diffusion assay. Results revealed that 3-(3-fluoro-4-piperazine-1-phenyl)-1,3-oxazolidin-2-ones doesn’t have significant antifungal activity against P. chrysogenum but Ox 1.3 & Ox 1.5 have shown potential inhibition of A. flavus comparable to that of standard oxytetracycline. This antifungal activity can be attribute to the 4-acetylpiperazinyl ring in 3-(3-fluoro-4-piperazine-1-phenyl)-1,3-oxazolidin-2-one. Further tailoring up the structure can augment the drug discovery. © 2011 IGJPS. All rights reserved.

In Vitro Study

Study Snapshot

3-(3-fluoro-4-piperazine-1-phenyl)-1,3-oxazolidin-2-ones show potential antifungal activity against Aspergillus flavus, with Ox 1.3 and Ox 1.5 showing inhibition comparable to standard oxytetracycline.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Preliminary Investigation of Antifungal Activity of 3-(3-fluoro-4- piperazine-1-phenyl)-1,3-oxazolidin-2-ones

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