Paper
In-vitro and In-vivo Anti-hyperglycemic Activities of Taxifolin and Its Derivatives isolated from Pigmented Rice (Oryzae sativa L. cv. Superhongmi).
Published Dec 27, 2019 · K. Yoon, Jung‐Yun Lee, Tae Yang Kim
Journal of agricultural and food chemistry
29
Citations
0
Influential Citations
Abstract
Superhongmi is a new rice variety, which was developed for the enrichment of bioactive compounds through cross-breeding three varieties of rice breeds in Korea. The HPLC/PDA/QTOF-MS analysis has revealed that superhongmi bran extract contained four taxifolin derivatives as well as cyanidin 3-glucoside. The high-performance countercurrent chromatography (CCC) and reversed-phase HPLC led to the isolation of aforementioned five compounds, and spectroscopic analysis identified cyanidin 3-glucoside (1), along with (2R,3R)-taxifolin 3-O--D-glucopyranoside (2), (2R,3R)-4'-O-methyltaxifolin 3-O--D-glucopyranoside (a novel compound) (3), (2R,3R)-taxifolin (4), and (2R,3R)-4'-O-methyltaxifolin (5). Compound 2 had the highest rat small intestinal sucrase inhibitory activity (0.54 mM) relevant for potentially managing postprandial hyperglycemia, followed by compound 1 (0.97 mM) and compound 4 (1.74 mM, IC50), respectively. The anti-hyperglycemic effect of compound 4 (taxifolin), a main peak in HPLC analysis was investigated using Sprague-Dawley (SD) rat model. Compared to a control, taxifolin treatment (p < 0.001) reduced significantly after sucrose loading the observed postprandial blood-glucose and the maximum blood glucose (Cmax) by 15% (203.60 ± 15.86 to 172.30 ± 12.74). These results indicate that taxifolin derivatives that inhibit the activity of carbohydrate hydrolyzing enzymes resulting to reduced dietary carbohydrate absorption can potential be used as a strategy to manage diabetes.
Taxifolin and its derivatives from Superhongmi rice can potentially reduce postprandial blood-glucose levels by 15%, potentially aiding in diabetes management.
Full text analysis coming soon...