Iodobenzene is shown to catalyze the 5-exo-dig cyclization of δ-alkynyl β-ketoesters under oxidative conditions that generate hypervalent iodine species in situ. The cyclopentane products contain adjacent quaternary and tertiary stereocenters which are generated with excellent diastereoselectivity.

Iodobenzene catalyzes the 5-exo-dig cyclization of -alkynyl -ketoesters under oxidative conditions, generating hypervalent iodine species and excellent diastereoselectivity in cyclopentane

Paper

Iodobenzene-catalyzed intramolecular oxidative cyclization reactions of δ-alkynyl β-ketoesters.

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