Paper
Iridium-catalyzed regio- and enantioselective allylic alkylation of fluorobis(phenylsulfonyl)methane.
Published Oct 28, 2009 · Wen-Bo Liu, Sheng-Cai Zheng, H. He
Chemical communications
Q1 SJR score
63
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0
Influential Citations
Abstract
Highly regio- and enantioselective allylic alkylation of fluorobis(phenylsulfonyl)methane (FBSM) has been realized by [Ir(COD)Cl](2)/phosphoramidite, affording enantiopure fluorobis(phenylsulfonyl)methylated compounds bearing a terminal alkene, which could be converted to monofluoro-methylated ibuprofen in just two steps without loss of the optical purity (95% ee).
Study Snapshot
Iridium-catalyzed allylic alkylation of fluorobis(phenylsulfonyl)methane allows for enantiopure compounds with a terminal alkene, which can be converted to monofluoro-methylated ibuprofen in
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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