Iridium(iii)-catalyzed regioselective C7-sulfonamidation of indoles.

doi:10.1039/c6ob00926c

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Iridium(iii)-catalyzed regioselective C7-sulfonamidation of indoles.

Published May 25, 2016 · Zengqiang Song, A. Antonchick

Organic & biomolecular chemistry

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Abstract

Iridium(iii)-catalyzed direct C7-sulfonamidation of indoles with sulfonyl azides is described. The developed method has good compatibility with diverse functional groups, providing various 7-amino-substituted indoles with good to excellent yields in a short time under mild reaction conditions. The key feature of the developed method is the regioselective functionalization at the C7-position of 2,3-unsubstituted indoles. Biologically active compounds can be obtained using this protocol. The application of the iridium(iii) catalyst and directing group plays a crucial role in the regioselectivity of the developed reaction.

Study Snapshot

This study presents a novel method for regioselective C7-sulfonamidation of indoles, providing various 7-amino-substituted indoles with good to excellent yields under mild reaction conditions, potentially leading to biologically active compounds.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Iridium(iii)-catalyzed regioselective C7-sulfonamidation of indoles.

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