Isoeugenol suppression of inducible nitric oxide synthase expression is mediated by down-regulation of NF-kappaB, ERK1/2, and p38 kinase.

doi:10.1016/J.EJPHAR.2007.07.034

Paper

Isoeugenol suppression of inducible nitric oxide synthase expression is mediated by down-regulation of NF-kappaB, ERK1/2, and p38 kinase.

Published Dec 8, 2007 · C. Choi, Kyung-Ran Park, Jung-Hee Lee

European journal of pharmacology

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69

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5

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Abstract

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In Vitro Study

Study Snapshot

Isoeugenol and its analogues inhibit nitric oxide production and iNOS expression in LPS-stimulated RAW 264.7 cells, partially by blocking phosphorylation of ERK1/2 and p38 kinase, degradation of I-kappaB

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Isoeugenol suppression of inducible nitric oxide synthase expression is mediated by down-regulation of NF-kappaB, ERK1/2, and p38 kinase.

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