Isolation and structural characterization of a new tadalafil analog (chloropropanoylpretadalafil) found in a dietary supplement.

doi:10.1016/j.jpba.2016.05.038

Paper

Isolation and structural characterization of a new tadalafil analog (chloropropanoylpretadalafil) found in a dietary supplement.

Published Sep 5, 2016 · S. Kern, Lisa M. Lorenz, A. Lanzarotta

Journal of pharmaceutical and biomedical analysis

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11

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Study Snapshot

Chloropropanoylpretadalafil, a new tadalafil analog found in a dietary supplement, has been identified and characterized.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Isolation and structural characterization of a new tadalafil analog (chloropropanoylpretadalafil) found in a dietary supplement.

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References

Citations

Analytical methods for the detection and characterization of unapproved phosphodiesterase type 5 inhibitors (PDE-5i) used in adulteration of dietary supplements- a review

Unapproved PDE-5 inhibitors in dietary supplements are mostly sildenafil analogues, and current analytical methods may not be sufficient for their detection and characterization.

Interpol review of controlled substances 2016–2019☆

This paper reviews forensic-relevant literature on controlled substances from 2016 to 2019 as part of the 19th Interpol International Forensic Science Managers Symposium.

Identification of Erectile Dysfunction Drugs in Dietary Supplements by Liquid Chromatography Ion Trap Mass Spectrometry

This study developed a quick and reliable method for identifying erectile dysfunction drugs in dietary supplements using HPLC coupled with ion trap mass spectrometry, saving time and solvents.

A review of synthetic phosphodiesterase type 5 inhibitors (PDE‐5i) found as adulterants in dietary supplements

Synthetic PDE-5i analogues are commonly found in dietary supplements, with tadalafil analogues increasing in popularity from 2015 to 2016, and most are found in Asian countries.

Simultaneous Orthogonal Drug Detection Using Fully Integrated Gas Chromatography with Fourier Transform Infrared Detection and Mass Spectrometric Detection

Using a fully integrated GC/FT-IR/MS instrument allows for a wider range of analytes and concentrations to be examined, reducing laboratory resources and time.

Synthesis and Structure Revision of Dimeric Tadalafil Analogue Adulterants in Dietary Supplements.

Dimeric tadalafil analogues synthesized using HATU can serve as reference standards for detecting illegal additions to dietary supplements, reducing public health risks.

Isolation and characterization of a novel dithio‐carbodenafil analogue from a health supplement

A novel dithio-carbodenafil analogue, 3,5-dimethylpiperazinyl dithio-desmethylcarbodenafil, was isolated and identified from a health supplement.

Adulterated pharmaceutical chemicals in botanical dietary supplements: novel screening approaches

Novel screening approaches using spectroscopic and chromatographic methods can effectively detect adulterants in botanical dietary supplements, reducing health risks to consumers.