Isolation and structural characterization of 2R, 3R taxifolin 3-O-rhamnoside from ethyl acetate extract of Hydnocarpus alpina and its hypoglycemic effect by attenuating hepatic key enzymes of glucose metabolism in streptozotocin-induced diabetic rats.

doi:10.1016/j.biochi.2015.02.003

Paper

Isolation and structural characterization of 2R, 3R taxifolin 3-O-rhamnoside from ethyl acetate extract of Hydnocarpus alpina and its hypoglycemic effect by attenuating hepatic key enzymes of glucose metabolism in streptozotocin-induced diabetic rats.

Published Apr 1, 2015 · R. Balamurugan, S. Vendan, A. Aravinthan

Biochimie

Q1 SJR score

19

Citations

1

Influential Citations

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Abstract

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Non-RCT

Animal Study

Study Snapshot

Rhamnoside from Hydnocarpus alpina tree effectively normalizes blood glucose, glycosylated hemoglobin, and liver enzymes in diabetic rats by increasing insulin secretion through a K+-ATP channels dependent signaling pathway.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Isolation and structural characterization of 2R, 3R taxifolin 3-O-rhamnoside from ethyl acetate extract of Hydnocarpus alpina and its hypoglycemic effect by attenuating hepatic key enzymes of glucose metabolism in streptozotocin-induced diabetic rats.

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References

Antihyperglycemic effect of fraxetin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-induced diabetic rats.

Fraxetin administration significantly reduces blood glucose levels and improves body weight in streptozotocin-induced diabetic rats, suggesting its potential as a diabetes treatment.

Efficacy of 20-OH-ecdysone on hepatic key enzymes of carbohydrate metabolism in streptozotocin induced diabetic rats.

20-OH-ecdysone effectively reduces plasma glucose levels in streptozotocin-induced diabetic rats, with comparable effects to glibenclamide.

Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus

Ficus deltoidea has the potential to be developed as an oral antidiabetic agent due to its ability to stimulate insulin secretion, enhance glucose uptake, and increase adiponectin secretion.

Modulatory effects of fisetin, a bioflavonoid, on hyperglycemia by attenuating the key enzymes of carbohydrate metabolism in hepatic and renal tissues in streptozotocin-induced diabetic rats.

Fisetin effectively reduces blood glucose levels and increases plasma insulin in diabetic rats by modulating key carbohydrate metabolism enzymes.

Anti-Diabetic Effect of Pectinase-Processed Ginseng Radix (GINST) in High Fat Diet-Fed ICR Mice

Ginseng radix (GINST) improves glucose tolerance and reduces insulin resistance in high fat diet-fed mice, suggesting potential therapeutic benefits for type 2 diabetes.

Citations

Caragana jubata ethanol extract ameliorates the symptoms of STZ-HFD-induced T2DM mice by PKC/GLUT4 pathway.

Caragana jubata ethanol extract improves blood sugar levels and insulin sensitivity in type 2 diabetes by activating the PKC pathway and promoting GLUT4 expression and fusion with the plasma membrane.

Quercetin and taxifolin enhance immunity in Chinese sucker (Myxocyprinus asiaticus) and increase its resistance to Aeromonas hydrophila.

Quercetin and taxifolin enhance Chinese sucker's immunity and resistance to Aeromonas hydrophila by boosting oxidative stress resistance and immunity.

Phytomedicine approach for management of diabetes mellitus: an overview of scientifically confirmed medicinal plants with hypoglycaemic properties and their probable mechanism of action

Medicinal plants with hypoglycemic properties show diverse mechanisms, with potential for drug discovery in diabetes management.

Modulation of Metabolic Pathways and Protection against Cadmium-Induced Disruptions with Taxifolin-Enriched Extract

Taxifolin-enriched extract (TEE) can potentially restore normal metabolic functions and reduce adverse impacts caused by cadmium chloride exposure by modulating metabolic pathways and restoring gene expression related to glucose metabolism and insulin regulation.

Venom Peptides, Polyphenols and Alkaloids: Are They the Next Antidiabetics That Will Preserve β-Cell Mass and Function in Type 2 Diabetes?

Polyphenols, alkaloids, and venom peptides from snakes, frogs, scorpions, and cone snails show potential as efficient antidiabetic medicines targeting pancreatic -cells, potentially tackling type 2 diabetes progression.