Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells.

doi:10.1016/j.taap.2012.09.022

Paper

Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells.

Published Nov 15, 2012 · Linli Yuan, Jing Wang, Haifang Xiao

Toxicology and applied pharmacology

Q2 SJR score

112

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2

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Abstract

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In Vitro Study

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Study Snapshot

Isoorientin induces apoptosis in HepG2 cancer cells through mitochondrial dysfunction and inhibition of PI3K/Akt signaling, suggesting potential as a therapeutic and chemopreventive agent for liver cancer.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Isoorientin induces apoptosis through mitochondrial dysfunction and inhibition of PI3K/Akt signaling pathway in HepG2 cancer cells.

References

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