Lanostane triterpenoids from Fomitopsis officinalis and their trypanocidal activity

doi:10.1007/s11418-018-1182-1

Paper

Lanostane triterpenoids from Fomitopsis officinalis and their trypanocidal activity

Published Feb 7, 2018 · Shinen Naranmandakh, T. Murata, Batsukh Odonbayar

Journal of Natural Medicines

Q1 SJR score

16

Citations

3

Influential Citations

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Abstract

Fomitopsis officinalis is a medicinal fungus, known as ‘Agarikon’, and is used traditionally in the treatment of asthma and rheumatism in Mongolia. The investigation of the chemical constituents of F. officinalis led to the isolation of 4 new lanostane triterpenoids together with 4 known triterpenoids. Inhibitory activity against Trypanosoma congolense, which causes fatal diseases in animals including livestock, was estimated for the isolated compounds. Compounds 2–5 and 8 exhibited moderate inhibition activities with IC50 values ranging from 7.0−27.1 µM.

In Vitro Study

Study Snapshot

Lanostane triterpenoids from Fomitopsis officinalis show moderate inhibitory activity against Trypanosoma congolense, potentially benefiting livestock health.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Lanostane triterpenoids from Fomitopsis officinalis and their trypanocidal activity

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