A lipid based depot (DepoFoam technology) for sustained release drug delivery.

doi:10.1016/S0163-7827(02)00004-8

Paper

DOI: 10.1016/S0163-7827(02)00004-8

A lipid based depot (DepoFoam technology) for sustained release drug delivery.

Published Sep 1, 2002 · S. Mantripragada

Progress in lipid research

Q1 SJR score

191

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Highly Cited

Study Snapshot

DepoFoam technology offers a novel approach to sustained-release drug delivery, allowing for large quantities of drugs in a small volume of injection, with controllable release rates from a few days to several weeks.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Full text analysis coming soon...

References

DOI:

Liposomes: Rational Design

Liposomes have diverse applications in various fields, including pharmaceuticals, biotechnology, and dermatology, with potential for clinical approval.

1998·112citations·A. Janoff

DOI: 10.1021/LA960218S

Topology of multivesicular liposomes, a model biliquid foam

The novel multivesicular liposome (MVL) structure resembles a gas-liquid foam, offering potential for drug delivery and demonstrating the polytetrahedral random close packing predicted for liquids and metallic glasses.

1996·64citations·M. Spector et al.·Langmuir

Langmuir

DOI:

Liposomes as Tools in Basic Research and Industry

Liposomes are useful tools in basic research and industry, serving as cell models, carriers of antigens, and tools for gene transfer, membrane fusion, and imaging.

1994·128citations·J. Philippot et al.

DOI: 10.1021/BI00369A056

Fraction of cholesterol undergoing spontaneous exchange between small unilamellar phosphatidylcholine vesicles.

Spontaneous exchange of cholesterol between phosphatidylcholine vesicles occurs at first-order, but 20% of total cholesterol remains nonexchangeable, with the size of this nonexchangeable pool varying based on phospholipid type and temperature.

1986·49citations·L. Bar et al.·Biochemistry

Biochemistry

DOI: 10.1016/0005-2736(83)90504-7

Preparation of multivesicular liposomes.

Multivesicular liposomes can effectively encapsulate materials from glucose to nucleic acids, with up to 89% encapsulation achieved.

1983·178citations·S. Kim et al.·Biochimica et biophysica acta

Biochimica et biophysica acta

DOI: 10.1007/978-1-59259-427-6_12

Sustained-Release Drug Delivery with DepoFoam

Sustained-release drug delivery systems enhance therapy effectiveness by prolonging drug half-life, maintaining therapeutic concentration, and reducing toxicity, while improving patient compliance and extending treatment costs.

2004·6citations·S. Mantripragada et al.

DOI: 10.1080/107175499267011

Distribution of Phospholipids and Triglycerides in Multivesicular Lipid Particles

Phospholipid and triglyceride distribution in multivesicular lipid particles (MLPs) and their precursors is crucial for controlled release of pharmaceuticals over a few days to weeks.

1999·36citations·J. Ellena et al.·Drug Delivery

Drug Delivery

Citations

DOI: 10.3390/pharmaceutics17020203

Sustained Delivery of Liraglutide Using Multivesicular Liposome Based on Mixed Phospholipids

The optimal release ratio of SPC and DEPC in multivesicular liposomes for liraglutide is 75:25, allowing sustained blood glucose control for 8 days.

2025·0citations·Runpeng Zhang et al.·Pharmaceutics

Pharmaceutics

DOI: 10.1016/j.ejpb.2025.114630

Bupivacaine multivesicular liposomes/meloxicam nanocrystals in a thermosensitive gel adapted to the "microenvironment" for long-term analgesia.

The novel injectable formulation H-MVL/MLX@GEL effectively alleviates pain for at least five days and reduces local inflammation by regulating the acidic microenvironment and alleviating irritation.

2025·0citations·Dongxu Gao et al.·European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

DOI: 10.1016/j.ejpb.2024.114577

Challenges in the development of long acting injectable multivesicular liposomes (DepoFoam® technology).

DepoFoam® technology offers sustained release pharmacokinetics and improved half-life, but challenges in development and approval require further research and development efforts.

2024·0citations·Ji Li et al.·European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V

DOI: 10.1080/17425247.2024.2374807

Injectable long-acting formulations (ILAFs) and manufacturing techniques.

Injectable long-acting formulations (ILAFs) improve patient compliance and reduce side effects by extending the half-life of active pharmaceutical ingredients, minimizing frequent doses and reducing the risk of side effects.

2024·0citations·Kosheli Thapa Magar et al.·Expert opinion on drug delivery

Expert opinion on drug delivery

DOI: 10.3390/ph17070879

Extended Release of Bupivacaine from Temperature-Responsive PNDJ Hydrogels Improves Postoperative Weight-Bearing in Rabbits Following Knee Surgery

SBG004, an extended-release bupivacaine formulation, provides longer analgesia than current local anesthetics for knee surgery, improving postoperative weight-bearing in rabbits.

2024·1citation·Derek J. Overstreet et al.·Pharmaceuticals

Pharmaceuticals

DOI: 10.3390/pharmaceutics16020287

Foams Set a New Pace for the Release of Diclofenac Sodium

Foams show promising potential as an alternative to traditional dermal carrier systems, offering faster drug release and permeation for diclofenac sodium treatment.

2024·0citations·Fanni Falusi et al.·Pharmaceutics

Pharmaceutics