Mechanism of 6-hydroxydopamine neurotoxicity.

doi:10.1007/978-3-7091-6842-4_7

Paper

Mechanism of 6-hydroxydopamine neurotoxicity.

Published Jan 1, 1997 · DOI · Y. Glinka, M. Gassen, M. Youdim

Journal of neural transmission. Supplementum

358

Citations

9

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Abstract

The catecholaminergic neurotoxin 6-hydroxydopamine (6-OHDA) has recently been found to be formed endogenously in patients suffering from Parkinson's disease. In this article, we highlight the latest findings on the biochemical mechanism of 6-OHDA toxicity. 6-OHDA has two ways of action: it easily forms free radicals and it is a potent inhibitor of the mitochondrial respiratory chain complexes I and IV. The inhibition of respiratory enzymes by 6-OHDA is reversible and insensitive towards radical scavengers and iron chelators with the exception of desferrioxamine. We conclude that free radicals are not involved in the interaction between 6-OHDA and the respiratory chain and that the two mechanisms are biochemically independent, although they may act synergistically in vivo.

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Study Snapshot

6-hydroxydopamine neurotoxicity involves two independent mechanisms: free radical formation and inhibition of mitochondrial respiratory chain complexes, which may act synergistically in vivo.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Mechanism of 6-hydroxydopamine neurotoxicity.

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