Mechanism of action of benzene toxicity: cell cycle suppression in hemopoietic progenitor cells (CFU-GM).

doi:10.1016/S0301-472X(00)00671-8

Paper

Mechanism of action of benzene toxicity: cell cycle suppression in hemopoietic progenitor cells (CFU-GM).

Published Mar 1, 2001 · B. Yoon, Y. Hirabayashi, Y. Kawasaki

Experimental hematology

Q1 SJR score

80

Citations

2

Influential Citations

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Non-RCT

Animal Study

Highly Cited

Study Snapshot

Benzene hematotoxicity suppresses the cell cycle of hemopoietic progenitor cells through p53-mediated overexpression of p21, leading to a dynamic change in hemopoiesis during and after exposure.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Mechanism of action of benzene toxicity: cell cycle suppression in hemopoietic progenitor cells (CFU-GM).

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References

Citations

Amelioration of Cytogenotoxic Damage in Drug Abusers Supplemented with Folic Acid

Folic acid supplementation significantly improves cytogenotoxic damage in drug abusers, reducing the frequency of nuclear abnormalities.

Deranged hembiosynthetic pathway in gasoline dispensers in Nigeria: Implications for risk of myeloproliferative disorders and chemoprevention

Benzene exposure in gasoline dispensers in Nigeria leads to increased phenol levels and decreased micronutrients, potentially increasing myelotoxicity and myeloproliferation risk.

Epigenetic Effects of Benzene in Hematologic Neoplasms: The Altered Gene Expression

Benzene exposure can cause hematological malignancies through genotoxic effects, oxidative stress, inflammation, and immunosuppression, but also through epigenetic changes, which may be targeted with pharmacological interventions.

E-cigarettes and health risks: more to the flavour than just the name.

The flavorant profile of E-liquids plays a crucial role in disrupting airway health by increasing bronchial epithelial cell apoptosis, causing alveolar macrophage phagocytic dysfunction, and altering airway cytokines.

Toxicity in hematopoietic stem cells from bone marrow and peripheral blood in mice after benzene exposure: Single-cell transcriptome sequencing analysis.

Benzene exposure causes hematotoxicity in mice, with key pathways in cancer, transcriptional misregulation, and hematopoietic cell lineage being affected.