Summary The molecular mechanism of action of the antitumor drug, methylthioinosine periodate oxidation product, was demonstrated. This periodate oxidation product (methylthioinosinedicarboxaldehyde) inhibited bovine pancreatic ribonuclease A. The inhibition was due to Schiff9s base formation with e-amino groups of lysine residues, one of which was in close proximity to the catalytic center of the enzyme.

The antitumor drug methylthioinosine periodate oxidation product inhibits ribonuclease A through Schiff9s base formation with lysine residues near the enzyme's catalytic center.

Paper

The molecular mechanism of action of methylthioinosinedicarboxaldehyde on ribonuclease A as a model system.

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