Molecular mechanism of biological action of the serotonergic neurotoxin 5,7-dihydroxytryptamine

doi:10.1016/0197-0186(88)90165-9

Paper

DOI: 10.1016/0197-0186(88)90165-9

Molecular mechanism of biological action of the serotonergic neurotoxin 5,7-dihydroxytryptamine

Published Dec 31, 1988 · A. Sinhababu, R. Borchardt

Neurochemistry International

Q2 SJR score

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

Study Snapshot

5,7-DHT neurodegeneration may be attributed to its unique mechanism of action, which involves incorporating oxygen into its molecules, producing 4,5,7-THTQ, and potentially causing hypoxia and protein crosslinking.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Full text analysis coming soon...

References

DOI: 10.1016/0361-9230(82)90128-9

Dihydroxytryptamines as tools to study the neurobiology of serotonin

Dihydroxytryptamines are effective tools for studying serotonin neurobiology, with their chemical properties, disposition in the biophase, and mechanism of action crucial for optimal application.

1982·66citations·H. Baumgarten et al.·Brain Research Bulletin

Brain Research Bulletin

DOI: 10.1111/j.1471-4159.1980.tb09016.x

Polarographic Measurements of Spontaneous and Mitochondria‐Promoted Oxidation of 5,6‐and 5,7‐Dihydroxytryptamine

Oxidation of 5,6 and 5,7DHT in the presence of rat liver mitochondria enhances their neurotoxic potency, suggesting their involvement in electron transfer in mitochondrial respiration.

1980·28citations·H. Klemm et al.·Journal of Neurochemistry

Journal of Neurochemistry

DOI: 10.1111/j.1471-4159.1979.tb04517.x

IN VITRO STUDIES ON THE INTERACTION OF BRAIN MONOAMINE OXIDASE WITH 5,6‐ AND 5,7‐DIHYDROXYTRYPTAMINE 1 2

Both 5,6 and 5,7DHT are metabolized by both MAO types (A and B), with 5,7 and 5,6DHT being preferred substrates of MAO A in deprenyl inhibition studies.

1979·11citations·H. Klemm et al.·Journal of Neurochemistry

Journal of Neurochemistry

DOI: 10.1016/s0026-895x(25)13536-0

Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro.

6-hydroxydopamine and 2,4,5-trihydroxyphenylalanine cause cell death through the production of reactive oxygen species, while dopamine and dopa may also be cytotoxic due to the reaction of quinone oxidation products with nucleophiles.

1978·966citations·D. Graham et al.·Molecular pharmacology

Molecular pharmacology

DOI: 10.1111/j.1749-6632.1978.tb31508.x

SYNTHESIS AND CHEMICAL PROPERTIES OF SOME INDOLE DERIVATIVES

Searching for neurotoxic indole derivatives with lesser side effects, we synthesized isomeric dihydroxytryptamines and their derivatives, which showed promising potential for inducing serotonin fiber degeneration.

1978·12citations·H. Schlossberger·Annals of the New York Academy of Sciences

Annals of the New York Academy of Sciences

DOI: 10.1111/j.1749-6632.1978.tb31509.x

INTERACTION OF 5,6‐ AND 5,7‐DIHYDROXYTRYPTAMINE WITH TISSUE MONOAMINE OXIDASE *

The neurotoxic mechanism of 5,6-DHT and 5,7-DHT is similar, with covalent binding of reactive intermediates to nucleophiles in proteins being the key factor in their neurotoxicity.

1978·13citations·H. Klemm et al.·Annals of the New York Academy of Sciences

Annals of the New York Academy of Sciences

DOI: 10.1111/j.1749-6632.1978.tb31511.x

MECHANISMS OF ACTION OF HYDROXYLATED PHENYLETHYLAMINE AND INDOLEAMINE NEUROTOXINS *

Hydrogen radicals play a critical role in the neurotoxicity of 6-OHDA and 5,7-DHT, suggesting a similar mechanism for these two neurotoxins on noradrenergic nerves.

1978·30citations·G. Cohen et al.·Annals of the New York Academy of Sciences

Annals of the New York Academy of Sciences

DOI: 10.1111/j.1749-6632.1978.tb31510.x

MECHANISM OF ACTION OF DIHYDROXYTRYPTAMINES

Dihydroxytryptamines selectively cytotoxicize central serotoninrgic heurons and peripheral noradrenergic neurons, with their mechanism of action involving oxidative stress and covalent protein interactions.

1978·20citations·C. Creveling et al.·Annals of the New York Academy of Sciences

Annals of the New York Academy of Sciences

Citations

DOI: 10.1007/s12264-018-0251-5

Microarray Analysis of Gene Expression Changes in Neuroplastin 65-Knockout Mice: Implications for Abnormal Cognition and Emotional Disorders

Np65-knockout mice exhibit abnormal cognition and emotional disorders due to altered gene expression and reduced brain development.

2018·9citations·Huanhuan Li et al.·Neuroscience Bulletin

Neuroscience Bulletin

DOI: 10.1673/031.003.1401

Effects of 5,7-dihydroxytriptamine (5,7-DHT) on circadian locomotor activity of the blow fly, Calliphora vicina

Serotonin plays a potential role in modulating circadian rhythms in insects, including regulation of locomotor activity levels.

2003·12citations·B. Cymborowski·Journal of Insect Science

Journal of Insect Science

DOI: 10.1016/S0306-3623(97)00440-0

Monoamine and iron-related toxicity: from "serotonin-binding proteins" to lipid peroxidation and apoptosis in PC12 cells.

Dopamine combined with iron induces lipid peroxidation and apoptosis in PC12 cells, potentially explaining neurodegenerative mechanisms in some disorders.

1998·22citations·C. Velez-Pardo et al.·General pharmacology

General pharmacology

DOI: 10.2108/zsj.15.317

Effects of 5,7-DHT Injection into the Optic Lobe on the Circadian Locomotor Rhythm in the Cricket, Gryllus bimaculatus

5,7-DHT injection into the optic lobe significantly reduces serotonin content, potentially impairing circadian locomotor rhythms in crickets.

1998·6citations·M. Germ et al.

DOI: 10.1016/0006-2952(96)00093-7

Redox cycling activity of monoamine-serotonin binding protein conjugates.

Monoamine-SBP conjugates of serotonin, dopamine, and related toxins can catalyze redox cycling reactions, potentially acting as "artificial quinoproteins."

1996·12citations·C. Velez-Pardo et al.·Biochemical pharmacology

Biochemical pharmacology