The mechanism of sodium fluoride and cycloheximide inhibition of hemoglobin biosynthesis in the cell-free reticulocyte system.

doi:10.1016/0022-2836(66)90079-9

Paper

DOI: 10.1016/0022-2836(66)90079-9

The mechanism of sodium fluoride and cycloheximide inhibition of hemoglobin biosynthesis in the cell-free reticulocyte system.

Published Oct 28, 1966 · S. Lin, R. Mosteller, B. Hardesty

Journal of molecular biology

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171

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

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Study Snapshot

Sodium fluoride and cycloheximide inhibit hemoglobin biosynthesis by inhibiting ribosome initiation and causing the breakdown of polysomes to single ribosomes in intact cells.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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References

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Re-evaluation of the hypothesis that LTP has two temporal phases and that the late phase is protein synthesis- dependent

The temporal distinction of LTP into early and late phases is a false dichotomy, and the rate of protein degradation may explain whether protein synthesis inhibitors affect LTP stabilization.

2015·0citations·A. Abbas

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Rocaglamide breaks TRAIL resistance in HTLV-1-associated adult T-cell leukemia/lymphoma by translational suppression of c-FLIP expression

Rocaglamide sensitizes HTLV-1-infected cells to TRAIL-induced apoptosis by downregulating c-FLIP expression, suggesting it may serve as an adjuvant for TRAIL-based anticancer therapy.

2011·70citations·M. Bleumink et al.·Cell Death and Differentiation

Cell Death and Differentiation

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The Acid Test of Fluoride: How pH Modulates Toxicity

The low pH environment of maturation stage ameloblasts increases fluoride uptake, leading to increased cell stress and dental fluorosis.

2010·54citations·Ramaswamy Sharma et al.·PLoS ONE

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Fluoride Induces Endoplasmic Reticulum Stress and Inhibits Protein Synthesis and Secretion

Low-dose fluoride exposure activates the unfolded protein response in ameloblasts, potentially impairing enamel development and contributing to dental fluorosis.

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The dissociation of rabbit reticulocyte ribosomes into subparticles active in protein synthesis.

Dissociation of rabbit reticulocyte ribosomes into subparticles is effective for protein synthesis, but fractionated subparticles are inactive in a cell-free system.

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