Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research.

doi:10.1016/j.tips.2008.01.007

Paper

Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research.

Published Apr 1, 2008 · M. Danhof, E. D. De Lange, O. Della Pasqua

Trends in pharmacological sciences

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291

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3

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Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

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Study Snapshot

Mechanism-based PK-PD modeling improves drug efficacy and safety predictions in translational research by distinguishing between drug-specific and biological system-specific properties.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Mechanism-based pharmacokinetic-pharmacodynamic (PK-PD) modeling in translational drug research.

References

Citations