Mechanisms involved in the antiplatelet activity of tetramethylpyrazine in human platelets.

doi:10.1016/S0049-3848(97)00253-3

Paper

DOI: 10.1016/S0049-3848(97)00253-3

Mechanisms involved in the antiplatelet activity of tetramethylpyrazine in human platelets.

Published Nov 1, 1997 · Joen-Rong Sheu, Y. Kan, W. C. Hung

Thrombosis research

Q1 SJR score

Citations

Influential Citations

Full textSemantic Scholar

Abstract

Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.

In Vitro Study

Study Snapshot

Tetramethylpyrazine inhibits platelet aggregation and ATP-release reaction in human platelets through two pathways: inhibiting phosphoinositide breakdown and thromboxane A2 formation at lower concentrations and binding to the glycoprotein IIb/IIIa complex at higher concentrations.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Sign up to use Study Snapshot

Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.

Create an account

Full text analysis coming soon...

References

DOI: 10.3181/00379727-213-44038

Triflavin, an Arg-Gly-Asp-Containing Peptide, Inhibits the Adhesion of Tumor Cells to Matrix Proteins via Binding to Multiple Integrin Receptors Expressed on Human Hepatoma Cells

Triflavin, a snake venom peptide, inhibits hepatoma cell adhesion to matrix proteins by binding to multiple integrin receptors on the surface of hepatoma cells.

1996·50citations·J. Sheu et al.·Proceedings of the Society for Experimental Biology and Medicine

Proceedings of the Society for Experimental Biology and Medicine

DOI: 10.1016/0006-291X(92)92337-W

Triflavin, an RGD-containing antiplatelet peptide, binds to GpIIIa of ADP-stimulated platelets.

Triflavin inhibits platelet aggregation by binding to GpIIIa, a protein close to which it interacts with fibrinogen receptors.

1992·56citations·J. Sheu et al.·Biochemical and biophysical research communications

Biochemical and biophysical research communications

DOI: 10.1042/BJ2770351

A potent antiplatelet peptide, triflavin, from Trimeresurus flavoviridis snake venom.

Triflavin, a peptide from Trimeresurus flavoviridis snake venom, effectively inhibits platelet aggregation by blocking fibrinogen binding to its receptors on platelet membranes.

1991·67citations·Tur-Fu Huang et al.·The Biochemical journal

The Biochemical journal

DOI: 10.1016/0049-3848(90)90170-H

Antithrombotic/antiplatelet activity of tetramethylpyrazine.

TMPZ, an active component found in certain plants, exhibits antithrombotic activity due to its potent antiplatelet effect, inhibiting platelet aggregation and calcium mobilization.

1990·44citations·S. Liu et al.·Thrombosis research

Thrombosis research

DOI: 10.1042/CS0770515

Effect of ligustrazine on pulmonary vascular changes induced by chronic hypoxia in rats.

Ligustrazine, a Chinese herb, dilates lung vessels and reverses hypoxic pulmonary vasoconstriction in rats, reducing pulmonary hypertrophy and muscularization.

1989·32citations·Y. Cai et al.·Clinical science

Clinical science

Citations

DOI: 10.2147/DDDT.S464910

Therapeutic Potential of Natural Resources Against Endometriosis: Current Advances and Future Perspectives

Natural resources, such as herbal and traditional Chinese medicine, show potential in treating endometriosis, offering an alternative or additional therapy to current drug and surgical treatments.

2024·0citations·Xia Gu et al.·Drug Design, Development and Therapy

Drug Design, Development and Therapy

DOI: 10.26689/jcnr.v8i6.7032

Research Progress on the Anti-Atherosclerotic Effect and Mechanism of Tetramethylpyrazine

Tetramethylpyrazine effectively reduces atherosclerosis by regulating lipid metabolism, inhibiting foam cell formation, alleviating inflammation, and inhibiting vascular calcification and abnormal platelet activation.

2024·0citations·Shengyang Gong et al.·Journal of Clinical and Nursing Research

Journal of Clinical and Nursing Research

DOI: 10.1016/j.pharmthera.2024.108656

Bibliometric analysis of research progress on tetramethylpyrazine and its effects on ischemia-reperfusion injury.

TMP shows significant protective effects on ischemia-reperfusion injury, but its bioavailability needs improvement for clinical applications.

2024·5citations·Mingzhu Qi et al.·Pharmacology & therapeutics

Pharmacology & therapeutics

DOI: 10.1016/j.ejphar.2023.175524

Effects of tetramethylpyrazine treatment in a rat model of spinal cord injury: A systematic review and meta-analysis.

TMP treatment can improve spinal cord injury outcomes in rats, but larger, high-quality studies are needed for verification.

2023·9citations·Gan Li et al.·European journal of pharmacology

European journal of pharmacology

DOI: 10.1097/MBC.0000000000001179

Application of microfluidic chip technology to study the inhibitory effect of tetramethylpyrazine on platelet aggregation, activation, and phosphatidylserine exposure mediated by pathological high shear rate

TMA effectively inhibits platelet aggregation, activation, and phosphatidylserine exposure in arterial vessels by inhibiting von Willebrand factor binding and partially through platelet P2Y12-ADP receptor pathway.

2022·5citations·Tian Zhang et al.·Blood Coagulation & Fibrinolysis

Blood Coagulation & Fibrinolysis