Paper
Cellular mechanisms of benzodiazepine action.
Published Apr 16, 1982 · R. E. Study, J. Barker
JAMA
120
Citations
1
Influential Citations
Abstract
BENZODIAZEPINES are in common clinical use because they possess a fortunate combination of important therapeutic properties. They are effective in the treatment of two common clinical conditions—anxiety and insomnia—and they are useful in the treatment of seizure disorders and certain kinds of spasticity as well. In addition to these therapeutic actions, these drugs lack significant side effects outside of the CNS and have low toxicity, factors that have contributed to their widespread clinical use. Since the introduction of chlordiazepoxide hydrochloride (Librium) in 1960, research into the cellular mechanisms of benzodiazepine action has increased in parallel with the use of these agents. In this review, some recent advances in elucidating the mechanisms of action of benzodiazepines in the CNS are described. The principal lines of basic research on benzodiazepines fall into two general categories: biochemical and electrophysiological. Although they will be discussed separately, they represent complementary strategies for achieving a comprehensive
Understanding of benzodiazepine action in the CNS can enhance their effectiveness in treating anxiety, insomnia, seizure disorders, and spasticity.
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