Paper
Mechanisms Contributing to the Phase-Dependent Regulation of Neurogenesis by the Novel Antidepressant, Agomelatine, in the Adult Rat Hippocampus
Published Jul 1, 2009 · A. Soumier, M. Banasr, S. Lortet
Neuropsychopharmacology
Q1 SJR score
173
Citations
9
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
Non-RCT
Animal Study
Rigorous Journal
Highly CitedStudy Snapshot
Agomelatine treatment promotes neurogenesis in the adult rat hippocampus, with a joint effect of melatonin agonism and 5-HT2C antagonism potentially contributing to its survival effect.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
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Citations
Agomelatine prevented depression in the chronic restraint stress model through enhanced catalase activity and halted oxidative stress
Agomelatine improves depression-like behavior in mice by enhancing catalase activity and reducing oxidative stress, without significantly altering the inflammatory pathway.
2024·1citation·Jiaxi Xu et al.·PLOS ONE
PLOS ONE
Neuropharmacologic modulation of the melatonergic system
Melatonergic agents and serotonin reuptake inhibitors can potentially alleviate various conditions by regulating circadian rhythms, melatonin secretion, and neurotransmitter systems.
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Neurotransmission, Vasculogenesis, and Osteogenesis Activities are Altered in the Aging Temporomandibular Joint of the Senescence-Accelerated Prone 8 Mouse Model.
Aging in the temporomandibular joint is associated with altered neurotransmitter, vasculogenesis, and osteogenesis pathways in the SAMP8 mouse model.
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Brain serotonin mediates neurogenesis, leading to therapeutic effects on depression-related states, with region-specific mechanisms in the hippocampus and subventricular zone.
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Agomelatine in the treatment of anhedonia, somatic symptoms, and sexual dysfunction in major depressive disorder
Agomelatine effectively improves anhedonic status, anxiety/somatic symptoms, and sexual dysfunction in major depressive disorder patients without causing serious adverse events.
2023·3citations·Juan Huang et al.·Frontiers in Psychiatry
Frontiers in Psychiatry