Mechanisms of inhibition of aldehyde dehydrogenase by nitroxyl, the active metabolite of the alcohol deterrent agent cyanamide.

doi:10.1016/S0006-2952(98)00080-X

Paper

Mechanisms of inhibition of aldehyde dehydrogenase by nitroxyl, the active metabolite of the alcohol deterrent agent cyanamide.

Published Jun 15, 1998 · E. Demaster, B. Redfern, Herbert T. Nagasawa

Biochemical pharmacology

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150

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4

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Abstract

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Nitroxyl, the active metabolite of cyanamide, inhibits aldehyde dehydrogenase in a pH-dependent manner, with two inhibitory forms of the enzyme formed, with reversible forms predominant at pH 8.5 and above.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Mechanisms of inhibition of aldehyde dehydrogenase by nitroxyl, the active metabolite of the alcohol deterrent agent cyanamide.

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References

Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion.

The structure of ALDH2, the enzyme linked to ethanol aversion, provides insights into its catalytic mechanism and potential drug targets for treating alcoholism.

The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD and the Rossmann fold

The first structure of an aldehyde dehydrogenase reveals a novel NAD binding mode, a new catalytic site, and a similar polypeptide fold to other ALDHs, suggesting a mechanism for enzymatic specificity and activity.

Mechanism for the inhibition of aldehyde dehydrogenase by nitric oxide.

Nitric oxide inhibits aldehyde dehydrogenase in Saccharomyces cerevisiae by oxidizing sulfhydryl groups in the enzyme's active site and affecting enzyme activity.

Inhibition of S-nitrosation of reduced glutathione in aerobic solutions of nitric oxide by phosphate and other inorganic anions.

Bifunctional anions, arsenate, phosphate, and pyrophosphate, significantly inhibit S-nitrosation of reduced glutathione in aerobic solutions of nitric oxide, accounting for 20 to 40% of inhibition.

Mechanism of Nitric Oxide Release from S-Nitrosothiols*

S-nitrosothiol decomposition, involving trace transition metal ions and reduced metal ions, plays a crucial role in nitric oxide biochemistry and signal transduction.

Citations

The chemistry of HNO-releasing compounds

HNO-releasing compounds exhibit diverse biological activity, with complex reaction mechanisms and diverse effects in chemical and biological studies.

Endogenous plant nitroxyl, a new component of nitric oxide biology.

Nitroxyl (HNO) was discovered in Arabidopsis thaliana, and its unique chemical properties require further study to determine its impact on physiological processes.

An activatable near-infrared fluorescent probe for tracking nitroxyl in vitro and in vivo

NHMC-P is a highly sensitive and selective near-infrared fluorescent probe for tracking nitroxyl in living organisms, aiding in HNO-related pathological studies.

The effects of hydrogen cyanamide (dormex) on the brain and lungs of albino rats and the potential protective impact of vitamin E

Vitamin E can protect albino rats from the toxic effects of hydrogen cyanamide (dormex), which is sprayed on grapes for early bud break.

Para-Substituted O-Benzyl Sulfohydroxamic Acid Derivatives as Redox-Triggered Nitroxyl (HNO) Sources

New redox-triggered nitroxyl sources were successfully prepared, offering potential for understanding nitroxyl's role in redox biology.