Medicinal Chemistry: Some 1‐[(Benzofuran‐2‐yl)methyl]imidazoles as Inhibitors of 17α‐Hydroxylase:17, 20‐lyase (P450 17) and Their Specificity Patterns

doi:10.1111/j.2042-7158.1998.tb03320.x

Paper

DOI: 10.1111/j.2042-7158.1998.tb03320.x

Medicinal Chemistry: Some 1‐[(Benzofuran‐2‐yl)methyl]imidazoles as Inhibitors of 17α‐Hydroxylase:17, 20‐lyase (P450 17) and Their Specificity Patterns

Published Oct 1, 1998 · S. A. Bahshwan, C. Owen, P. Nicholls

Journal of Pharmacy and Pharmacology

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Abstract

Four 1‐[(benzofuran‐2‐yl)methyl]imidazoles (1–4) have been evaluated as in‐vitro inhibitors of human testicular and bovine adrenal microsomal 17α‐hydroxylase: 17,20‐lyase (P450 17) as potential anti‐prostatic agents. Their specificity towards other steroidogenic and liver enzymes has been compared with that of ketoconazole.

Study Snapshot

The 1[(benzofuran-2yl)methyl]imidazoles show potential as anti-prostatic agents with similar specificity to ketoconazole towards other steroidogenic and liver enzymes.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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