Paper
Mesovarial Leiomyomas in Rats in a Chronic Toxicity Study of Soterenol Hydrochloride
Published Sep 1, 1971 · L. W. Nelson, W. A. Kelly
Veterinary Pathology
Q1 SJR score
25
Citations
1
Influential Citations
Abstract
In an 18-month oral toxicity study of soterenol hydrochloride, a stimulant of the β-adrenergic receptors, mesovarial leiomyomas were observed in three of 30 low-dose, six of 30 middle-dose and 10 of 30 high-dose rats. There was also an increase in the prevalence of ovarian cysts and of focal hyperplasia of smooth muscle in the mesovaria in the treated rats, especially in the high-dose group.
Non-RCT
Animal StudyStudy Snapshot
Soterenol hydrochloride may increase the risk of mesovarial leiomyomas and ovarian cysts in rats, with higher doses potentially leading to increased mesovarial smooth muscle hyperplasia.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
Pharmacologic potency and selectivity of a new bronchodilator agent: soterenol (MJ 1992).
Soterenol is a highly effective bronchodilator agent with greater duration and lower cardiovascular responses compared to isoproterenol, offering potential for use in various animal species.
1968·27citations·K. Dungan et al.·The Journal of pharmacology and experimental therapeutics
The Journal of pharmacology and experimental therapeutics
Spontaneous Tumors in Holtzman-Source Rats of Various Ages
Spontaneous tumor development in Holtzman-source rats aged 1-18 months is comparable to lifetime studies, highlighting the need for data on tumors in other age groups for better toxicological study interpretation.
1968·70citations·J. Schardein et al.·Veterinary Pathology
Veterinary Pathology
Protracted effects of repeated doses of x-ray irradiation in rats.
Repeated X-ray irradiation in rats leads to carcinogenesis, with a preference for endocrine organs and related systems, and may contribute to vascular impairment and genetic factors.
1963·13citations·Berdjis Cc·Experimental and Molecular Pathology
Experimental and Molecular Pathology
Spontaneous neoplasms in the albino rat.
Albino rats are susceptible to spontaneous neoplasms, with phaeochromocytoma being the most common, and the endocrine glands being the main site of these tumors.
1958·52citations·C. Gilbert et al.·The South African journal of medical sciences
The South African journal of medical sciences
A transplantable ovarian papillary adenocarcinoma of the rat with ascites implants in the ovary.
Ovarian tumors in rats are rare, but this study shows that ascites implants in the ovary can effectively transplant a functional ovarian tumor into a rat.
1952·9citations·A. Symeonidis et al.·Journal of the National Cancer Institute
Journal of the National Cancer Institute
A transplantable functional ovarian tumor occurring spontaneously in a rat.
Spontaneous functional ovarian tumors in rats are rare, but this one shows high endocrine activity and has grown readily on serial passage.
1950·16citations·R. Iglesias et al.·Cancer research
Cancer research
The respective roles of longevity and genetic specificity in the occurrence of spontaneous tumors in the hybrids between two inbred lines of rats.
Genetic specificity plays a significant role in spontaneous tumors in rats, while longevity factors play a determining role in the incidence of many neoplasms.
1946·60citations·W. F. Dunning et al.·Cancer research
Cancer research
Citations
Selection of appropriate tumour data sets for Benchmark Dose Modelling (BMD) and derivation of a Margin of Exposure (MoE) for substances that are genotoxic and carcinogenic: considerations of biological relevance of tumour type, data quality and uncertainty assessment.
This paper provides guidance on selecting and modeling carcinogenicity data for human hazard assessment, considering tumor type relevance, data quality, and uncertainty assessment in the Margin of Exposure approach.
2014·26citations·L. Edler et al.·Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
The preclinical toxicology of salmeterol hydroxynaphthoate
Salmeterol hydroxynaphthoate (Serevent) is a well-tolerated and safe inhaled beta2-adrenoceptor agonist with no evidence of genotoxic potential.
2010·8citations·K. Owen et al.·Human & Experimental Toxicology
Human & Experimental Toxicology
Toxicokinetic and Mechanistic Considerations in the Interpretation of the Rodent Bioassay
Toxicokinetic and mechanistic data can help determine the significance of rodent bioassay data for human safety, aiding in determining human risk from nongenotoxic chemicals.
1994·12citations·J. MacDonald et al.·Toxicologic Pathology
Toxicologic Pathology
Drug-Induced Mesovarial Leiomyomas in the Rat—A Review and Additional Data
Long-term treatment with beta2-adrenoceptor stimulant drugs can cause benign mesovarial leiomyomas in rats, but no known reports of this response in human patients.
1993·6citations·W. A. Kelly et al.·International Journal of Toxicology
International Journal of Toxicology