Paper
The metabolism of aminoacetone to methylglyoxal by semicarbazide-sensitive amine oxidase in human umbilical artery.
Published Apr 1, 1992 · G. A. Lyles, Janette Chalmers
Biochemical pharmacology
Q1 SJR score
202
Citations
5
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro Study
Highly CitedStudy Snapshot
Aminoacetone is an endogenously occurring amine with a lower threshold for metabolism by semicarbazide-sensitive amine oxidase in human umbilical artery, potentially impacting human vascular function.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
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The glyoxalase system plays a fundamental role in cell growth, vesicle mobilization, and plays a role in tumor growth and diabetes development, with potential implications for treating associated clinical complications.
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Further Studies on the Metabolism of Methylamine by Semicarbazide‐sensitive Amine Oxidase Activities in Human Plasma, Umbilical Artery and Rat Aorta
Semicarbazide-sensitive amine oxidase activities in human plasma, rat aorta, and human umbilical artery metabolize methylamine, suggesting its involvement in endogenous methylamine turnover.
1990·53citations·G. A. Lyles et al.·Journal of Pharmacy and Pharmacology
Journal of Pharmacy and Pharmacology
Deamination of aliphatic amines of different chain lengths by rat liver monoamine oxidase A and B
Rat liver monoamine oxidase deaminates aliphatic amines with different chain lengths, with n-Pentylamine, n-hexylamine, n-heptylamine, n-octylamine, n-nony
1989·37citations·P. Yu·Journal of Pharmacy and Pharmacology
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Properties of a Semicarbazide‐Sensitive Amine Oxidase in Human Umbilical Artery
Semicarbazide-sensitive amine oxidase (SSAO) is present in human umbilical artery, with methylamine potentially being a better substrate for SSAO than aromatic biogenic amines.
1988·44citations·Elaine Precious et al.·Journal of Pharmacy and Pharmacology
Journal of Pharmacy and Pharmacology
Deamination of methylamine by semicarbazide-sensitive amine oxidase in human umbilical artery and rat aorta.
Semicarbazide-sensitive amine oxidase (SSAO) is predominantly responsible for deamination of methylamine and benzylamine in human and rat arteries, with differences in biochemical properties between species.
1988·120citations·Elaine Precious et al.·Biochemical pharmacology
Biochemical pharmacology
Citations
The dual role of methylglyoxal in plant stress response and regulation of DJ-1 protein.
Methylglyoxal plays a dual role in plant salt stress response, with the DJ-1 protein playing a crucial role in detoxification and reducing glycation damage caused by MG.
2024·0citations·Yutong Sun et al.·Physiologia plantarum
Physiologia plantarum
Exploration of Glyoxals’ Level Changes in Endoplasmic Reticulum during Ferroptosis by a Photocaged Fluorescent Probe
Ferroptosis increases glyoxal levels in endoplasmic reticulum, highlighting a previously overlooked characteristic of ferroptosis.
2024·0citations·Wanjin Xing et al.·Sensors and Actuators B: Chemical
Sensors and Actuators B: Chemical
Methylglyoxal in Cardiometabolic Disorders: Routes Leading to Pathology Counterbalanced by Treatment Strategies
Methylglyoxal (MGO) plays a role in various cardiometabolic disorders, and treatment strategies aimed at reducing its generation and AGEs' impact are crucial for effective management.
2023·3citations·I. Berdowska et al.·Molecules
Molecules
Glyoxalase 2: Towards a Broader View of the Second Player of the Glyoxalase System
Glyoxalase 2 plays a role in multiple regulatory pathways, potentially impacting diseases like cancer and oxidative stress-related diseases.
2022·16citations·Andrea Scirè et al.·Antioxidants
Antioxidants
Folic acid deficiency increases sensitivity to DNA damage by glucose and methylglyoxal
Folic acid deficiency increases sensitivity to DNA damage caused by glucose and methylglyoxal, suggesting individuals with type 2 diabetes may be at higher risk of chromosomal instability.
2022·3citations·Leigh Donnellan et al.·Mutagenesis
Mutagenesis
Interactions of epicatechin and cysteine with certain other dicarbonyl scavengers during their reaction with methylglyoxal under simulated physiological conditions.
Epicatechin and cysteine show synergistic scavenging potential when combined with other dicarbonyl scavengers, while epicatechin interacts antagonistically with compounds that stimulate its oxidation.
2021·3citations·Ezgi Doğan Cömert et al.·Food chemistry
Food chemistry
Overview of the Neuroprotective Effects of the MAO-Inhibiting Antidepressant Phenelzine
Phenelzine, a MAO-inhibiting antidepressant, has neuroprotective properties, including effects on brain balance, nitrative stress reduction, and potential anticonvulsant actions.
2021·18citations·D. Matveychuk et al.·Cellular and Molecular Neurobiology
Cellular and Molecular Neurobiology
Aerobic co-oxidation of hemoglobin and aminoacetone, a putative source of methylglyoxal.
Aminoacetone-produced methylglyoxal can cause structural changes in hemoglobin, potentially contributing to human diseases linked to hemoglobin dysfunctions and metabolic alterations.
2021·4citations·Luiz D. Ramos et al.·Free radical biology & medicine
Free radical biology & medicine