Paper
Metabotropic Glutamate Receptor 5 in Natural Killer Cells Attenuates Liver Fibrosis by Exerting Cytotoxicity to Activated Stellate Cells
Published May 1, 2021 · Won-Mook Choi, Tom Ryu, Jun‐Hee Lee
Hepatology
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Abstract
The important roles of glutamate and metabotropic glutamate receptor 5 (mGluR5) in HSCs have recently been reported in various liver diseases; however, the mechanism linking the glutamine/glutamate metabolism and mGluR5 in liver fibrosis remains unclear. Here, we report that mGluR5 activation in natural killer (NK) cells attenuates liver fibrosis through increased cytotoxicity and interferon‐γ (IFN‐γ) production in both mice and humans.
Rigorous JournalActivating metabotropic glutamate receptor 5 in natural killer cells reduces liver fibrosis by increasing cytotoxicity and interferon- production in both mice and humans.
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