Paper
An Efficient Method for the p-Methoxybenzylation of Hydroxy Groups with 2-(4-Methoxybenzyloxy)-3-nitropyridine.
Published May 1, 2001 · Masakazu Nakano, Wataru Kikuchi, J. Matsuo
Chemistry Letters
Q2 SJR score
16
Citations
0
Influential Citations
Abstract
2-(4-Methoxybenzyloxy)-3-nitropyridine (PMBONPy), easily prepared from 2-chloro-3-nitropyridine and p-methoxybenzyl (PMB) alcohol, reacts with various types of hydroxy groups in the presence of a catalytic amount of trimethylsilyl triflate (Me3SiOTf) to give the corresponding PMB ethers in high yields under mild conditions.
Study Snapshot
This method efficiently produces p-methoxybenzylated hydroxy groups in high yields under mild conditions, making it a useful tool for preparing various ethers.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
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Chemoselective Oxidation of p-Methoxybenzyl Ethers by an Electronically Tuned Nitroxyl Radical Catalyst.
The electronically tuned nitroxyl radical catalyst 1 effectively oxidizes p-methoxybenzyl ethers, resulting in carbonyl compounds with high specific activity.
2020·13citations·Shohei Hamada et al.·Organic letters
Organic letters
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NaOt-Bu in DMSO effectively performs rapid p-methoxybenzylation of hydroxy and amide groups at room temperature, without needing activating reagents like tetrabutylammonium iodide.
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Tetrahedron Letters
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Organic letters
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Synthesis and stereochemical determination of an antiparasitic pseudo-aminal type monoterpene indole alkaloid
16-hydroxy-16,22-dihydroapparicine, a pseudo-aminal type monoterpene indole alkaloid, shows weak antimalarial activity against chloroquine-resistant Plasmodium falciparum (K1 strain).
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Tetrahedron Letters
Structure determination and total synthesis of (+)-16-hydroxy-16,22-dihydroapparicine.
This study successfully synthesized (+)-16-hydroxy-16,22-dihydroapparicine and demonstrated its antimalarial activity against chloroquine-resistant Plasmodium falciparum parasites.
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Chemistry