Alternative and efficient method for the preparation of 2-acetamidobenzimidazoles

doi:10.21608/EJCHEM.2021.53188.3102

Paper

Alternative and efficient method for the preparation of 2-acetamidobenzimidazoles

Published Feb 13, 2021 · B. Elmuradov, A. Abdurazakov, R. Okmanov

The Egyptian Journal of Chemistry

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Abstract

An alternative method for the synthesis of acetamidobenzimidazoles (3-6) has been developed, including the reacylation of methylbenzimidazol-2-ylcarbamate (carbendazim, MBC, 1) under the action of aliphatic and aromatic carboxylic acids. It was shown that with an increase in the size of the alkyl group and the reaction temperature (in the case of butyric acid), due to the decomposition of the resulting product, the yield of the target acyl products sharply decreases. The obtained compounds are homologues of the anthelmintic drug N-(1H-benzimidazol-2-yl) acetamide (2acetylaminobenzimidazole, 3). A possible mechanism of reacylation is presented.

Study Snapshot

This study developed an efficient method for preparing 2-acetamidobenzimidazoles (3-6) by reacylation of methylbenzimidazol-2-ylcarbamate with aliphatic and aromatic carboxylic acids, yielding homologues of the anthelmintic drug N-

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Alternative and efficient method for the preparation of 2-acetamidobenzimidazoles

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