Methyl methanesulfonate induces apoptosis in p53-deficient H1299 and Hep3B cells through a caspase 2- and mitochondria-associated pathway.

doi:10.1016/j.etap.2012.09.019

Paper

Methyl methanesulfonate induces apoptosis in p53-deficient H1299 and Hep3B cells through a caspase 2- and mitochondria-associated pathway.

Published Nov 1, 2012 · Ying Jiang, Xiaoyun Zhang, Li Sun

Environmental toxicology and pharmacology

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13

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0

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Abstract

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In Vitro Study

Study Snapshot

Methyl methanesulfonate (MMS) induces apoptosis in p53-deficient H1299 and Hep3B cells through a caspase 2- and mitochondria-associated pathway, demonstrating a p53- and p73-independent mechanism.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Methyl methanesulfonate induces apoptosis in p53-deficient H1299 and Hep3B cells through a caspase 2- and mitochondria-associated pathway.

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