Paper
Methylgerambullin Derived From Plant Glyccsmis Pentaphylla (Retz) Correa. Mediates Anti-Hepatocellular Carcinoma Cancer Effect by Activating Mitochondrial and Endoplasmic Reticulum Stress Signaling and Inhibiting AKT and STAT3 Pathways.
Published Jan 30, 2021 · Chaoqun Wu, Guangwen Shu, Huiqi Huang
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
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Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
Methylgerambullin, a component of Glycosmis pentaphylla plant, inhibits liver cancer cell proliferation by inducing mitochondrial apoptosis, activating ERS signaling pathways, and inhibiting Akt and STAT3 pathways.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Full text analysis coming soon...
References
Therapeutic potential of hesperidin and its aglycone hesperetin: Cell cycle regulation and apoptosis induction in cancer models.
Citrus flavanones hesperidin and hesperetin show potential antiproliferative effects in cancer models, with complex effects depending on cell lines and exposure conditions.
2020·85citations·J. M. P. Ferreira de Oliveira et al.·Phytomedicine : international journal of phytotherapy and phytopharmacology
Phytomedicine : international journal of phytotherapy and phytopharmacology
Challenges in liver cancer and possible treatment approaches.
New treatment options using natural compounds and nanotechnology may improve liver cancer outcomes with lower systemic toxicity and fewer side effects.
2020·998citations·David Anwanwan et al.·Biochimica et biophysica acta. Reviews on cancer
Biochimica et biophysica acta. Reviews on cancer
Natural products in licorice for the therapy of liver diseases: Progress and future opportunities.
Licorice-derived bioactive ingredients show promising therapeutic potential for treating liver diseases and drug-induced liver injury through multi-targeting mechanisms.
2019·194citations·Xiaojiaoyang Li et al.·Pharmacological research
Pharmacological research
Isovaleric acid and avicequinone-C are Chikungunya virus resistance principles in Glycosmis pentaphylla (Retz.) Correa
Oral administration of tender leaves of Glycosmis pentaphylla effectively prevents chikungunya virus infection, with compounds isovaleric acid and avicequinone-C showing potential as antiviral principles.
2019·45citations·O. Brinda et al.·Journal of Vector Borne Diseases
Journal of Vector Borne Diseases
Citations
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Two new sulfur-containing amides, glylucidamides C-D, and 12 known analogues were isolated from Glycosmis lucida leaves, showing potential anti-inflammatory properties.
2024·0citations·Shou-Yuan Wu et al.·Natural product research
Natural product research
A New Acridone Alkaloid from the Leaves of Glycosmis lucida
Lucidaine A, a new acridone alkaloid, was isolated from Glycosmis lucida leaves, with two known analogues 2 and 3.
2023·1citation·Shou-Yuan Wu et al.·Chemistry of Natural Compounds
Chemistry of Natural Compounds
Prenylated sulfonyl amides from the leaves of Glycosmis pentaphylla and their potential anti-proliferative and anti-inflammatory activities
Six sulfur-containing amides isolated from Glycosmis pentaphylla leaves show potential anti-inflammatory and anti-proliferative activities, with compound 4 showing the highest anti-inflammatory activity.
2022·2citations·Wenli Xie et al.·Arabian Journal of Chemistry
Arabian Journal of Chemistry
Dehydrocostus lactone inhibits the proliferation of esophageal cancer cells in vivo and in vitro through ROS-mediated apoptosis and autophagy.
Dehydrocostus lactone (DHL) inhibits esophageal cancer cell proliferation through ROS-mediated apoptosis and autophagy, suggesting it as a potential chemotherapeutic drug for esophageal cancer.
2022·10citations·Yu Peng et al.·Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Zn2+ protect cardiac H9c2 cells from endoplasmic reticulum stress by preventing mPTP opening through MCU.
Zn2+ protects cardiac cells from endoplasmic reticulum stress by elevating calcium and closing the mitochondrial permeability transition pore through MCU.
2022·6citations·Yang Zhao et al.·Cellular signalling
Cellular signalling
A composition of bractatin and neobractatin from the fruits of Garcinia bracteata induces apoptosis in throat cancer through the endoplasmic reticulum stress, mitochondrial apoptotic and Akt pathways
CPX, a composition of bractatin and neobractatin from Garcinia bracteata fruits, shows potential as a chemotherapeutic drug for throat cancer by inducing apoptosis through endoplasmic reticulum stress, mitochondrial apop
2021·6citations·Huiqi Huang et al.·Journal of Functional Foods
Journal of Functional Foods
Unusual oximes with anti-inflammatory activities from Glycosmis craibii
Two new aldoximes A-B and two known analogues from Glycosmis craibii show remarkable anti-inflammatory properties, inhibiting nitric oxide production in mouse macrophages.
2021·4citations·Shou-Yuan Wu et al.·Phytochemistry Letters
Phytochemistry Letters