Paper
Methylglyoxal inhibits nuclear division through alterations in vacuolar morphology and accumulation of Atg18 on the vacuolar membrane in Saccharomyces cerevisiae
Published Aug 17, 2020 · W. Nomura, M. Aoki, Y. Inoue
Scientific Reports
Q1 SJR score
8
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro Study
Rigorous JournalStudy Snapshot
Methylglyoxal inhibits nuclear division in Saccharomyces cerevisiae by increasing phosphatidylinositol 3,5-bisphosphate levels and altering vacuolar morphology, without affecting known checkpoint machinery.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
Sign up to use Study Snapshot
Consensus is limited without an account. Create an account or sign in to get more searches and use the Study Snapshot.
Full text analysis coming soon...
References
Toxicity of dihydroxyacetone is exerted through the formation of methylglyoxal in Saccharomyces cerevisiae: effects on actin polarity and nuclear division.
Dihydroxyacetone toxicity in yeast cells is primarily due to its spontaneous conversion to methylglyoxal, which causes depolarization of actin, morphological changes in vacuoles, and inhibition of nuclear division.
2018·5citations·W. Nomura et al.·The Biochemical journal
The Biochemical journal
Effects of the Reactive Metabolite Methylglyoxal on Cellular Signalling, Insulin Action and Metabolism - What We Know in Mammals and What We Can Learn From Yeast.
Methylglyoxal (MG) triggers diabetic complications by inducing molecular changes in cells, and yeast as a simple model organism can provide valuable information on general defense pathways in response to MG stress.
2018·8citations·J. Zemva et al.·Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
Big Lessons from Little Yeast: Budding and Fission Yeast Centrosome Structure, Duplication, and Function.
Analysis of yeast centrosomes has advanced our understanding of centrosomes and nuclear envelope events, advancing our understanding of cell division and nuclear events in single-celled organisms.
2017·53citations·Ann M. Cavanaugh et al.·Annual review of genetics
Annual review of genetics
Membrane scission driven by the PROPPIN Atg18
The yeast PROPPIN Atg18 carries membrane scission activity, driving tubulation and scission of giant unilamellar vesicles, suggesting that membrane scission may be a generic function of this protein family.
2017·63citations·Navin Gopaldass et al.·The EMBO Journal
The EMBO Journal
Phosphatidylinositol 3,5-bisphosphate is involved in methylglyoxal-induced activation of the Mpk1 mitogen-activated protein kinase cascade in Saccharomyces cerevisiae
PtdIns(3,5)P2) plays a crucial role in methylglyoxal-induced activation of the Mpk1 MAPK cascade and cellular adaptation to methylglyoxal-induced stress in yeast.
2017·7citations·W. Nomura et al.·The Journal of Biological Chemistry
The Journal of Biological Chemistry
Citations
Activation of the cell wall integrity pathway negatively regulates TORC2-Ypk1/2 signaling through blocking eisosome disassembly in Saccharomyces cerevisiae
The cell wall integrity pathway negatively regulates TORC2-Ypk1/2 signaling, ensuring proper stress response to cell wall damage in Saccharomyces cerevisiae.
2024·1citation·Wataru Nomura et al.·Communications Biology
Communications Biology
Activation of the DNA damage checkpoint perturbs asymmetric localization of Kar9 to spindle pole bodies in Saccharomyces cerevisiae.
Activating the DNA damage checkpoint pathway disrupts asymmetric Kar9 localization, affecting proper positioning of spindle pole bodies during cell cycle progression.
2023·0citations·Momoko Hayashida et al.·Biochemical and biophysical research communications
Biochemical and biophysical research communications
The signalling lipid PI3,5P2 is essential for timely mitotic exit
PI3,5P2 plays a crucial role in promoting timely mitotic exit, with elevated levels accelerating it in defective cells, partly through impairment of Kin4, a key enzyme in mitotic exit.
2023·3citations·M. huda et al.·Open Biology
Open Biology
Detoxification of the post-harvest antifungal pesticide thiabendazole by cold atmospheric plasma.
Cold atmospheric plasma irradiation effectively detoxifies and degrades pesticide residues without causing damage to agricultural products, maintaining food safety.
2023·2citations·Shizu Fukuda et al.·Journal of bioscience and bioengineering
Journal of bioscience and bioengineering
α-Arrestins maintain phospholipid balance and Atg18 distribution to permit efficient autophagy
-arrestins play a crucial role in maintaining phospholipid balance and Atg18 distribution, enabling efficient autophagy, which helps cells survive nutrient starvation by degrading parts of themselves.
2022·0citations·Ray W. Bowman et al.·bioRxiv
bioRxiv
Nuclear ingression of cytoplasmic bodies accompanies a boost in autophagy
The nuclear envelope around the nucleolus undergoes a new remodeling event, leading to the nuclear engulfment of globular cytoplasmic portions and a boost in autophagy, potentially impacting metabolic adaptation.
2022·10citations·Manon Garcia et al.·Life Science Alliance
Life Science Alliance
Negative curvature-promoting lipids instruct nuclear ingression of low autophagic potential vacuoles
Negative curvature-promoting lipids, such as phosphatidic acid and sterols, drive the nuclear ingression of low autophagic potential vacuoles, optimizing cargo interaction with functional vacuoles.
2021·2citations·Manon Garcia et al.·bioRxiv
bioRxiv