Paper

Microwave assisted synthesis of 2-(4-substituted piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile as a new class of serotonin 5-HT3 receptor antagonists.

Published Oct 18, 2004 · DOI · R. Mahesh, R. V. Perumal, Pandi Vijaya Pandi

Bioorganic & medicinal chemistry letters

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Abstract

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In Vitro Study

Study Snapshot

Microwave assisted synthesis of 2-(4-substituted piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile 6d shows promising serotonin 5-HT3 receptor antagonism in Guinea pig ileum.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Microwave assisted synthesis of 2-(4-substituted piperazin-1-yl)-1,8-naphthyridine-3-carbonitrile as a new class of serotonin 5-HT3 receptor antagonists.

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