Abstract The microwave-induced synthesis of pyrazolo[3,4-d]pyrimidines 4 in the reaction of N4-substituted-2,4-diamino-6-chloro-5-carbaldehydes 3 with hydrazine is described here. Precursors 3 have been prepared by the mono-amination of 2-amino-4,6-dichloropyrimidine-5-carbaldehyde 2 with aliphatic and aromatic amines. The reaction times with primary amines were relatively shorter than for secondary amines.

Microwave-induced synthesis of pyrazolo[3,4-d]pyrimidines from 2-amino-4,6-dichloropyrimidine-5-carbaldehyde under solvent-free conditions demonstrates shorter reaction times for primary amines compared to secondary amines.

Paper

Microwave-Assisted Synthesis of Pyrazolo[3,4-d]pyrimidines from 2-Amino-4,6-dichloropyrimidine-5-carbaldehyde under Solvent-Free Conditions.

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