[Synthetic mineralocorticoid, clinical application of fludrocortisone acetate (Florinef)].

Paper

[Synthetic mineralocorticoid, clinical application of fludrocortisone acetate (Florinef)].

Published Mar 1, 1994 · Y. Igarashi

Nihon rinsho. Japanese journal of clinical medicine

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2

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Abstract

Fludrocortisone acetate (Florinef), a 9 alpha-fluorinated derivative of hydrocortisone, has strong mineralocorticoid activity. From the calculated values in a tracer study, the divided dose regimen is recommended. Florinef has been widely used in the treatment of salt-wasting congenital adrenal hyperplasia (CAH). A tentative guideline for the treatment of salt-wasting CAH was described and its usefulness was discussed.

Study Snapshot

Fludrocortisone acetate (Florinef) is a widely used treatment for salt-wasting congenital adrenal hyperplasia, with a divided dose regimen recommended for optimal results.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

[Synthetic mineralocorticoid, clinical application of fludrocortisone acetate (Florinef)].

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References

Citations

Experimental Cardiac Hypertrophy Induced by Oral Administration of Mineralocorticoid and Saline in Rats

Orally administered fludrocortisone/salt effectively induces moderate myocardial hypertrophy in rats without heart failure in 4 weeks, providing a low-cost model for hypertrophic heart disease.

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Prednisolone inhibits platelet aggregation, platelet-monocyte interactions, and thrombus formation, potentially impacting haemostasis and thrombosis through selective regulation of P2Y12 ADP receptor signaling.