Mirtazapine is a new antidepressant that falls into the general class of receptor‐blocking drugs rather than being an uptake or enzyme inhibitor. It can be described as a noradrenergic and specific serotonergic antidepressant (NaSSA). The unique pharmacology of mirtazapine means that it has a very different side effect profile from the tricyclic antidcpressants, producing less α1 adrenergic and musearinic blockade. and the selective serotonin reuptake inhibitors (SSRIs) and the serotonin‐noradrenaline reuptake inhibitors (SNRls), causing much less nausea and sexual dysfunction by virtue of its blockade of 5‐HT2 and 5‐HT3 receptors.

Mirtazapine is a unique antidepressant with a different side effect profile than tricyclic antidepressants and SSRIs, causing less nausea and sexual dysfunction due to its blockade of 5HT2 and 5HT3 receptors.

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Mirtazapine: pharmacology in relation to adverse effects

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