Mn(III)-Mediated Cascade Cyclization of 3-Isocyano-[1,1'-biphenyl]-2-carbonitrile with Arylboronic Acid: Construction of Pyrrolopyridine Derivatives.

doi:10.1021/acs.orglett.8b03868

Paper

Mn(III)-Mediated Cascade Cyclization of 3-Isocyano-[1,1'-biphenyl]-2-carbonitrile with Arylboronic Acid: Construction of Pyrrolopyridine Derivatives.

Published Jan 11, 2019 · Pei Xu, Yi-ming Zhu, Fei Wang

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Abstract

A Mn(III) mediated cascade cyclization of new designed multifunctionalized 3-isocyano-[1,1'-biphenyl]-2-carbonitrile with arylboronic acid to construct pyrrolopyridine derivatives is developed. A series of pyrroloporidine compounds have been constructed through the formation of two new C-C bonds and one C-N bond via a radical pathway.

Study Snapshot

Mn(III)-mediated cascade cyclization of 3-isocyano-[1,1'-biphenyl]-2-carbonitrile with arylboronic acid allows for the construction of pyrrolopyridine derivatives with unique properties.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Mn(III)-Mediated Cascade Cyclization of 3-Isocyano-[1,1'-biphenyl]-2-carbonitrile with Arylboronic Acid: Construction of Pyrrolopyridine Derivatives.

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References

Citations

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Mn-Catalyzed Electrooxidative Radical Cascade Cyclization for the Synthesis of 6-Phosphorylated Quinoxalino[2,1-b]quinazolin-12-ones.

Mn-catalyzed electrooxidative radical cascade cyclization effectively synthesizes 6-phosphorylated quinoxalino[2,1-b]quinazolin-12-ones in moderate to good yields for potential medicinal value.

Synthesis of Polycyclic Pyrrolopyridine Derivatives via Multicomponent Synthesis of 1,5‐Diketones

This two-step process allows for the easy synthesis of polycyclic pyrrolopyridine derivatives with bioactive properties, metal-free conditions, and easy purification methods.

Visible-Light-Promoted Cascade Cyclization of 3-Ethynyl-[1,1'-biphenyl]-2-Carbonitriles with Unsaturated α-Bromocarbonyls.

Visible-light-promoted cascade cyclization of 3-ethynyl-[1,1'-biphenyl]-2-carbonitriles with unsaturated -bromocarbonyls allows for the synthesis of tetrahydrobenzo[m

Visible Light-Induced Decomposition of Acyl Peroxides Using Isocyanides: Synthesis of Heteroarenes by Radical Cascade Cyclization.

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Mn(III)-Mediated Radical Addition/Cyclization of Isocyanides with Aryl Boronic Acids/Diarylphosphine Oxides: Access to 11-Functionalized Dibenzodiazepines.

This study developed a Mn(III)-mediated radical addition/cyclization reaction for efficiently constructing 11-arylated/-phosphorylated dibenzodiazepines under mild reaction conditions, offering novel access to functionalized seven-membered N-heterocycles.

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The divergent reaction of isocyanides with o-bromobenzaldehydes leads to the synthesis of isoindolinone-derived ketenimines and lactams, with high yields and mild conditions.

Design, Synthesis and Biological Evaluation of Arylpyridin-2-yl Guanidine Derivatives and Cyclic Mimetics as Novel MSK1 Inhibitors. An Application in an Asthma Model

The non-cytotoxic 2-aminobenzimidazole 49d shows the most potent inhibitory activity against MSK1 and inflammatory cell recruitment in an asthma mouse model.