Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection

doi:10.1016/j.ijantimicag.2020.105960

Paper

Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection

Published Apr 3, 2020 · J. Fantini, Coralie Di Scala, H. Chahinian

International Journal of Antimicrobial Agents

Q1 SJR score

482

Citations

26

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Abstract

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In Vitro Study

Highly Cited

Study Snapshot

Chloroquine and its derivative hydroxychloroquine effectively treat SARS-CoV-2 infection by binding to sialic acids and gangliosides, preventing viral S protein binding to gangliosides.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection

References

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