Modulation of SIRT1-mediated signaling cascades in the liver contributes to the amelioration of nonalcoholic steatohepatitis in high fat fed middle-aged LDL receptor knockout mice by dihydromyricetin.

doi:10.1016/j.bcp.2020.113927

Paper

Modulation of SIRT1-mediated signaling cascades in the liver contributes to the amelioration of nonalcoholic steatohepatitis in high fat fed middle-aged LDL receptor knockout mice by dihydromyricetin.

Published Mar 23, 2020 · Yi Zeng, Y. Hua, Wei Wang

Biochemical pharmacology

Q1 SJR score

34

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Abstract

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Non-RCT

Animal Study

Study Snapshot

Dihydromyricetin (DMY) improves nonalcoholic steatohepatitis symptoms in mice by modulating SIRT1-mediated signaling cascades, suggesting it as a potential therapeutic candidate for human NASH.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

Modulation of SIRT1-mediated signaling cascades in the liver contributes to the amelioration of nonalcoholic steatohepatitis in high fat fed middle-aged LDL receptor knockout mice by dihydromyricetin.

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