Paper
Mono-(2-ethylhexyl) phthalate affects the steroidogenesis in rat Leydig cells through provoking ROS perturbation.
Published Sep 1, 2012 · Yan Zhao, H. Ao, Li Chen
Toxicology in vitro : an international journal published in association with BIBRA
Q2 SJR score
74
Citations
1
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro Study
Highly CitedStudy Snapshot
Mono-(2-ethylhexyl) phthalate (MEHP) affects steroidogenesis in adult rat Leydig cells by provoking reactive oxygen species perturbation and affecting enzyme activities, potentially causing biphasic effects on androgen production.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Involvement of testicular growth factors in fetal Leydig cell aggregation after exposure to phthalate in utero
Fetal exposure to DEHP affects Leydig cell number, distribution, and steroidogenic capacity, with abnormal expressions of IGF1, KITL, and LIF genes potentially contributing to reproductive toxicity.
2008·153citations·Han Lin et al.·Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences
Mono-(2-ethylhexyl) phthalate increases spermatocyte mitochondrial peroxiredoxin 3 and cyclooxygenase 2.
Phtalate exposure disrupts mitochondrial antioxidant defenses in male germ cells, potentially contributing to disruption of spermatogenesis without inducing cell death.
2008·67citations·Thomas M. Onorato et al.·Journal of andrology
Journal of andrology
Mono-(2-ethylhexyl) phthalate stimulates basal steroidogenesis by a cAMP-independent mechanism in mouse gonadal cells of both sexes.
MEHP, the active metabolite of di-(2-ethylhexyl) phthalate (DEHP), can stimulate gonadal steroidogenesis in both sexes through a cAMP- and StAR-independent mechanism, potentially affecting puberty onset and
2008·74citations·David Gunnarsson et al.·Reproduction
Reproduction
Potential adverse effects of phthalic acid esters on human health: a review of recent studies on reproduction.
Phtalic acid esters may cause reproductive and developmental toxicities in humans, but current data on exposure and toxicokinetics are inconsistent, and it is not yet possible to conclusively determine their harmfulness for human reproduction.
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Regulatory toxicology and pharmacology : RTP
Phthalate ester toxicity in Leydig cells: developmental timing and dosage considerations.
Phthalate ester toxicity in Leydig cells can cause testicular dysgenesis syndrome, with fetal exposure leading to reduced Leydig cell numbers and steroidogenic competence, potentially increasing the risk of testicular cancer.
2007·156citations·R. Ge et al.·Reproductive toxicology
Reproductive toxicology
Citations
Di-(2-ethylhexyl) phthalate induces prepubertal testicular injury through MAM-related mitochondrial calcium overload in Leydig and Sertoli cell apoptosis.
Prepubertal exposure to DEHP causes testicular injury through MAM-related mitochondrial calcium overload and Leydig and Sertoli cell apoptosis.
2024·1citation·Jun-ke Wang et al.·Toxicology
Toxicology
Deoxynivalenol Inhibits Progenitor Leydig Cell Development by Stimulating Mitochondrial Fission in Rats.
Deoxynivalenol disrupts progenitor Leydig cell development in prepubertal rats by stimulating mitochondrial fission, reducing testosterone levels and impairing maturation.
2024·3citations·Jin Yang et al.·Journal of agricultural and food chemistry
Journal of agricultural and food chemistry
Alleviative effect of quercetin against reproductive toxicity induced by chronic exposure to the mixture of phthalates in male rats.
Quercetin can reduce male reproductive toxicity caused by a mixture of phthalates, potentially due to restored steroid hormone metabolism regulation.
2024·3citations·L. Xia et al.·Ecotoxicology and environmental safety
Ecotoxicology and environmental safety
FDX1 regulates leydig cell ferroptosis mediates PM2.5-induced testicular dysfunction of mice.
PM2.5 exposure leads to testicular dysfunction in mice by promoting steroidogenesis and ferroptosis, leading to decreased sperm quality and increased testosterone levels.
2023·8citations·Lipeng Li et al.·Ecotoxicology and environmental safety
Ecotoxicology and environmental safety
Trichlorfon blocks androgen synthesis and metabolism in rat immature Leydig cells.
Trichlorfon inhibits androgen production in rat immature Leydig cells by downregulating steroidogenesis-related genes and antioxidants.
2023·1citation·Huan Chen et al.·Reproductive toxicology
Reproductive toxicology
The negative impact of phthalates on male reproductive system and fertility
Phtalates negatively impact the male reproductive system and fertility, with some potentially being potential reprotoxicants.
2023·0citations·A. Sedova et al.·Andrology and Genital Surgery
Andrology and Genital Surgery