Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyridine-3,5-dicarbonitriles.

doi:10.1016/j.bmc.2010.06.095

Paper

Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyridine-3,5-dicarbonitriles.

Published Aug 15, 2010 · Abdelouahid Samadi, J. Marco-Contelles, E. Soriano

Bioorganic & medicinal chemistry

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47

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0

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Abstract

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In Vitro Study

Study Snapshot

These new compounds show potential as multipotent therapeutic molecules for treating Alzheimer's and neuronal vascular diseases by targeting cholinergic dysfunction and oxidative stress.

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

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Paper

Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chloropyridine-3,5-dicarbonitriles.

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References

Citations

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Identifying Possible AChE Inhibitors from Drug-like Molecules via Machine Learning and Experimental Studies

Machine learning and experimental studies identified two potent AChE inhibitors, benzyl trifluoromethyl ketone and trifluoromethylstyryl ketone, with potential for Alzheimer's disease therapy.

Alzheimer's disease: Updated multi-targets therapeutics are in clinical and in progress.

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2-amino-4-aryl-3,5-dicarbonitrile-6-thiopyridines show potential as new antimicrobial drugs, with their antibacterial activity depending on their structure and ability to affect bacteria's lipopolysaccharide.

Tacrines as Therapeutic Agents for Alzheimer's Disease. V. Recent Developments

Recent developments in Alzheimer's disease therapy include non-hepatotoxic tacrine analogues and multitarget tacrines, which combine cholinesterase inhibition with modulation of other biological targets.

In silico modeling for dual inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes in Alzheimer's disease

This study developed 2D-QSAR models to predict inhibitory activity of acetylcholinesterase and butyrylcholinesterase enzymes in Alzheimer's disease, identifying structural features that may contribute to inhibitory activity.

Antibacterial activity of 2-amino-3-cyanopyridine derivatives

The synthesized 2-amino-4-aryl-3-cyanopyridines show substantial antibacterial activity against Gram-negative bacteria E. coli and Gram-positive B. subtilis.

Synthesis, biological evaluation, and molecular modeling of nitrile‐containing compounds: Exploring multiple activities as anti‐Alzheimer agents

Nitrile-containing compounds with dual MAO and AChE inhibitory activities show potential as anti-Alzheimer agents, with 63 showing the most effective disaggregation of A1-42 fibrils.