Paper
N, N‐diisopropyl‐bis(4‐chlorobenzyl) phosphoramidite: A versatile phosphitylating agent for the phosphorylation of hydroxy amino acids and preparation of protected phosphopeptides
Published Jan 1, 1990 · H. de Bont, J. V. van Boom, R. Liskamp
Recueil des Travaux Chimiques des Pays-Bas
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Abstract
N, N-diisopropyl-bis(4-chlorobenzyl) phosphoramidite is an easily accessible phosphitylating agent, which readily phosphorylates Boc-Ser-OMe, Boc-Thr-OMe and Boc-Tyr-OMe in good to high yields after t-BuOOH or MCPBA oxidation. The Boc-group can be removed without affecting the phosphate 4-chlorobenzyl groups and vice versa. Extension of the Boc-deprotected phosphoamino acids with a subsequent amino acid yields the corresponding protected phosphopeptides
N, N-diisopropyl-bis(4-chlorobenzyl) phosphoramidite is a versatile phosphitylating agent for phosphorylating hydroxy amino acids and preparing protected phosphopeptides.
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