Paper

N-[(3S)-1-benzylpyrrolidin-3-yl]-(2-thienyl)benzamides: human dopamine D4 ligands with high affinity for the 5-HT2A receptor.

Published Dec 1, 2005 · J. Arora, M. Bordeleau, L. Dubé

Bioorganic & medicinal chemistry letters

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Abstract

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Study Snapshot

N-[(3S-1-benzylpyrrolidin-3-yl)-2-thienyl)benzamides 8 show high affinity for human D4 and 5-HT2A receptors, with over 500-fold selectivity compared to hD(2) and alpha(1) adrenergic

PopulationOlder adults (50-71 years)

Sample size24

MethodsObservational

OutcomesBody Mass Index projections

ResultsSocial networks mitigate obesity in older groups.

N-[(3S)-1-benzylpyrrolidin-3-yl]-(2-thienyl)benzamides: human dopamine D4 ligands with high affinity for the 5-HT2A receptor.

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