Paper
N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin suppresses growth and migration of human lung cancer cells.
Published Dec 15, 2010 · Yunxue Zhao, Wenjia Liu, Ying Zhou
Bioorganic & medicinal chemistry letters
Q2 SJR score
23
Citations
0
Influential Citations
Abstract
Abstract hidden due to publisher request; this does not indicate any issues with the research. Click the full text link above to read the abstract and view the original source.
In Vitro StudyStudy Snapshot
N-(8-(3-ethynylphenoxy)octyl-1-deoxynojirimycin1) effectively suppresses lung cancer cell growth and migration by inducing G1 phase cell cycle arrest and apoptosis.
PopulationOlder adults (50-71 years)
Sample size24
MethodsObservational
OutcomesBody Mass Index projections
ResultsSocial networks mitigate obesity in older groups.
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References
Cell migration-the role of integrin glycosylation.
Integrin glycosylation can regulate cell migration, potentially leading to novel diagnostic and therapeutic approaches.
2010·165citations·M. Janik et al.·Biochimica et biophysica acta
Biochimica et biophysica acta
Imaging of Apoptosis
Molecular imaging agents can detect specific biochemical changes in cells undergoing apoptosis, providing potential targets for targeted therapies in cancer and cardiovascular diseases.
2008·110citations·J. Tait·Journal of Nuclear Medicine
Journal of Nuclear Medicine
Hybrids of 1-deoxynojirimycin and aryl-1,2,3-triazoles and biological studies related to angiogenesis.
The novel agent inhibits angiogenesis by inhibiting -glucosidase and endothelial cell growth, with a distinct mechanism of action from fumagillin and its analogues.
2008·25citations·Yunxue Zhao et al.·Bioorganic & medicinal chemistry
Bioorganic & medicinal chemistry
Cancer Statistics, 2008
Cancer death rates have decreased since 1990, but cancer still kills more people under 85 than heart disease.
2008·10378citations·A. Jemal et al.·CA: A Cancer Journal for Clinicians
CA: A Cancer Journal for Clinicians
Hybrid angiogenesis inhibitors: synthesis and biological evaluation of bifunctional compounds based on 1-deoxynojirimycin and aryl-1,2,3-triazoles.
Bifunctional compounds based on 1-deoxynojirimycin and 5-aryl-1,2,3-triazole show potential as more potent angiogenesis inhibitors than either compound alone.
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2024·1citation·Susanne Suely Santos da Fonseca et al.·Frontiers in Chemical Engineering
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