N-Acylated N-methylcarbamates have been prepared and tested for contact/stomach poison and systemic insecticidal activities, mammalian toxicity and in vitro anticholinesterase activity. The N-acyl derivatives in general have lower mammalian toxicities and somewhat lower insecticidal activities than the corresponding unacylated N-methylcarbamates and are relatively poor inhibitors of bee cholinesterase. Tentative reasons are given for these effects.

N-acylated N-methylcarbamates have lower mammalian toxicities and slightly lower insecticidal activities than unacylated N-methylcarbamates, and are less effective inhibitors of bee cholinesterase.

Paper

N-Acylation of N-methylcarbamate insecticides and its effect on biological activity.

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